Sort   by:  
 Page size 
TranscriptomicsInvestigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders (ASD) by microRNA expression profiling of lymphoblastoid cell lines
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by abnormalities in reciprocal social interactions and language development and/or usage, and by restricted interests and repetitive behaviors. Differential gene expression of neurologically relevant genes in lymphoblasto...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-21086 | biostudies-arrayexpress
TranscriptomicsGene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by delayed/abnormal language development, deficits in social interaction, repetitive behaviors and restricted interests. The heterogeneity in clinical presentation of ASD, likely due to different etiologies, complicates ...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-15402 | biostudies-arrayexpress
TranscriptomicsGenome-wide Identification of Transcriptional Targets of RORA Reveals Direct Regulation of Multiple Genes Associated with Autism Spectrum Disorder
Background: We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). Our independent cohort studies have consistently demonstrated the reduction of RORA transcript and/or protein levels i...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-45756 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of lymphoblastoid cell lines from autistic and nonaffected sib pairs
Despite the identification of numerous autism susceptibility genes, the pathobiology of autism remains unknown. The present “case-control” study takes a global approach to understanding the molecular basis of autism spectrum disorders based upon large-scale gene expression profiling. DNA micro...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-15451 | biostudies-arrayexpress
TranscriptomicsPropionic Acid Induces Autistic-like Gene Expression Profiles, Inhibits Neurite Outgrowth, and Promotes Neurodegeneration in Cells from Non-Autistic Individuals
In this study, we investigated PPA-induced changes in gene expression profiles of lymphoblastoid cell lines (LCLs) from unaffected individuals, compared with gene expression profiles of LCLs from sex-matched siblings with ASD. Global gene expression profiling analysis revealed that 96 genes in LCLs ...
ORGANISM(S): Homo sapiens 
2011-09-15 | E-GEOD-32136 | biostudies-arrayexpress
TranscriptomicsSmall ncRNA expression-profiling of blood from Hemophilia A patients identifies miR-1246 as a potential regulator of Factor 8 gene
Hemophilia A (HA) is a bleeding disorder caused by deficiency of functional plasma clotting factor VIII (FVIII). In addition to genetic mutations in the gene encoding FVIII (F8), there is evidence that other molecular mechanisms may be involved in the pathobiology of HA. In this study, global small ...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-65581 | biostudies-arrayexpress
Sort   by:  
 Page size