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UnknownMaintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin.
Not available
S-EPMC7478974 | biostudies-literature
TranscriptomicsTranscription profiling of mouse SRF-null or control cardiomyocytes to study roles of the serum response factor in regulating contractile apparatus gene expression.
Serum Response Factor (SRF) is a transcriptional regulator required for mesodermal development. Numerous studies have implicated SRF as a central regulator of muscle gene expression and myogenesis. In this present study we used a loss of function approach to delineate the role of SRF in cardiac myoc...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3181 | biostudies-arrayexpress
UnknownThe novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling.
Not available
S-EPMC5602380 | biostudies-literature
UnknownCardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2.
Not available
S-EPMC6715661 | biostudies-literature
UnknownMyopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.
Not available
S-EPMC2169455 | biostudies-literature
UnknownMuscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.
Not available
S-EPMC9109819 | biostudies-literature
ProteomicsMolecular basis of F-actin regulation and sarcomere assembly via myotilin
Sarcomeres, the basic contractile units of striated muscle cells, contain arrays of thin (actin) and thick (myosin) filaments that slide past each other during contraction. The Ig-like domain containing protein myotilin provides structural integrity to Z-discs—the boundaries between adjacent sarcome...
ORGANISM(S): Homo sapiens (Human) 
2021-02-22 | PXD024301 | Pride
Sarcomeric z-disc  f-actin binding  myotilin  α-actinin-2  integrative structural model of f-actin:myotilin  competitive tropomyosin binding  z-disc-assembly regulation Cross-linking mass spectrometry Lc-ms/ms 
UnknownNovel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications (PTMs) in Skeletal Muscles Identified by Top-down Proteomics.
Not available
S-EPMC5750843 | biostudies-literature
UnknownDeconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Not available
S-EPMC7305127 | biostudies-literature
UnknownFacioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a dynamic nuclear and sarcomeric protein.
Not available
S-EPMC3030934 | biostudies-literature
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