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ProteomicsA mass spectrometry-based proteomics strategy to detect long-chain S-acylated peptides
Long-chain S-acylation is the addition of long-chain fatty acids to cysteine residues on proteins. This lipid modification is essential for protein membrane association and signalling but presents analytical challenges due to both its hydrophobicity and the labile nature of thioester bonds. We devel...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD057394 | Pride
Liquid chromatography Hydrophobicity Thioester stability Tandem mass spectrometry Long-chain s-acylation 
ProteomicsS-palmitoylation during retinoic acid induced neuronal differentiation of SH-SY5Y neuroblastoma cells
S-palmitoylation is the covalent attachment of palmitic acid to cysteine residues through a thioester bond. S-palmitoylation is highly abundant in neurons, where it plays a fundamental role in neuronal development. In addition, S-palmitoylation is associated with many neurodegenerative diseases, inc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040613 | Pride
Acyl-biotin exchange Lipid metabolic labelling Protein s-palmitoylation Sh-sy5y differentiation Retinoic acid Mass spectrometry-based proteomics 
TranscriptomicsTranscriptional profiling of mouse bone marrow-derived macrophages (BMDMs) upon treatment with the S-palmitoylation inhibitor 2BP and/or myelin
The formation of inflammatory foamy macrophages hinders brain repair in multiple sclerosis. Therefore, the phenotype of the macrophages can determine the repair status of brain lesions. Here, we established the impact of the general S-palmitoylation inhibitor 2BP on the phenotype of bone marrow-deri...
ORGANISM(S): Mus musculus 
2026-10-27 | E-MTAB-15390 | biostudies-arrayexpress
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