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ProteomicsA mass spectrometry-based proteomics strategy to detect long-chain S-acylated peptides
Long-chain S-acylation is the addition of long-chain fatty acids to cysteine residues on proteins. This lipid modification is essential for protein membrane association and signalling but presents analytical challenges due to both its hydrophobicity and the labile nature of thioester bonds. We devel...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD057394 | Pride
Liquid chromatography Hydrophobicity Thioester stability Tandem mass spectrometry Long-chain s-acylation 
ProteomicsS-palmitoylation during retinoic acid induced neuronal differentiation of SH-SY5Y neuroblastoma cells
S-palmitoylation is the covalent attachment of palmitic acid to cysteine residues through a thioester bond. S-palmitoylation is highly abundant in neurons, where it plays a fundamental role in neuronal development. In addition, S-palmitoylation is associated with many neurodegenerative diseases, inc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040613 | Pride
Acyl-biotin exchange Lipid metabolic labelling Protein s-palmitoylation Sh-sy5y differentiation Retinoic acid Mass spectrometry-based proteomics 
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