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TranscriptomicsComparison of stimulatory and inhibitory dendritic cell subsets reveals new role of DC in granulomatous infection
Myeloid dendritic cells (DC) and macrophages play an important role in pathogen sensing and antimicrobial defense. Recently we demonstrated that infection of human DC with intracellular bacterium Listeria monocytogenes (L.monocytogenes) leads to the induction of the immunoinhibitory enzyme indoleami...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-9946 | biostudies-arrayexpress
TranscriptomicsComparative global transcriptomic profiling of human ES and iPSs cells and their derived microdissected cardiac clusters
Recent establishment of induced pluripotent stem (iPS) cells opened new avenues for generating human patient-specific stem cell derivatives that can be used for in vitro modeling of human disease, drug development and cell replacement therapy. In this study we analyzed the molecular and functional p...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-17579 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of murine ES and iPS cells, embryoid bodies, and ES and IPS cell-derived cardiomyocytes
In this study we have compared functional and molecular properties of highly purified murine induced pluripotent stem (iPS) cell- and embryonic stem (ES) cell-derived cardiomyocytes (CM). In order to obtain large amounts of purified CM, we have generated a transgenic murine iPS cell line, which expr...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-18514 | biostudies-arrayexpress
TranscriptomicsInduced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-Derived Differences in DNA Methylation Profiles
Reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is an epigenetic phenomenon. It has been suggested that iPSC retain some tissue-specific memory whereas little is known about inter-individual epigenetic variation of iPSC clones. In this study we have reprogrammed mesenchymal...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-GEOD-34688 | biostudies-arrayexpress
TranscriptomicsPluripotent Stem Cells Escape From Senescence-Associated DNA Methylation Changes [Illumina]
Pluripotent stem cells evade replicative senescence, whereas other primary cells lose their proliferation and differentiation potential after a limited number of cell divisions M-bM-^@M-^S and this is accompanied by specific senescence-associated DNA methylation (SA-DNAm) changes. Here, we investiga...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-37066 | biostudies-arrayexpress
TranscriptomicsPluripotent Stem Cells Escape From Senescence-Associated DNA Methylation Changes
This SuperSeries is composed of the following subset Series: GSE37065: Long-term culture associated gene expression changes in MSC [Affymetrix] GSE37066: Pluripotent Stem Cells Escape From Senescence-Associated DNA Methylation Changes [Illumina] GSE38806: Gene expression profiles of induced pluripot...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-37067 | biostudies-arrayexpress
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