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TranscriptomicsOncolytic Reovirus mediates innate-driven SARS-CoV-2 elimination in the absence of cell toxicity
Interplay between type I interferon (IFN) driven innate responses and viral antagonism strongly influences SARS-CoV-2 transmission and the COVID-19 disease course. Hence, variant adaptation includes diminished induction of IFN stimulated genes (ISG) and/or evasion of their effector functions. Exogen...
ORGANISM(S): Homo sapiens 
2026-04-15 | E-MTAB-16855 | biostudies-arrayexpress
MetabolomicsRegulatory Role of the VCL/ICAM-1 Pathway in Inflammatory Exudative Damage to the Gas-Blood Barrier in SARS-CoV-2 Infection: New Insights from the Omicron Paradigm
Infections by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from the initial Wildtype (WT) variant in Wuhan, China, to later variants including Omicron, have showcased a diverse spectrum of symptoms. This diversity underscores the need for ongoing exploration into the vir...
2025-02-28 | MTBLS12231 | MetaboLights
TranscriptomicsResponses to SARS-CoV-2 variants in hACE2 transgenic mice
hACE2 transgenic mice were infected with the original SARS-CoV-2 strain (B.1) and the Beta (B.1.351) variant. Lung and spleen samples were collected 1 day post infection (DPI), 3 DPI and 5 DPI, and mRNA was sequenced.
ORGANISM(S): Mus musculus 
2023-09-22 | E-MTAB-13308 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response of human primary astrocytes to two different variants of SARS-CoV-2
A pivotal role of astrocytes in the pathophysiology of CNS disorders during the SARS-CoV-2 infection of brain has been proposed. Thus, the study was performed to reveal astrocyte response to infection caused by either Omicron or Delta variant.
ORGANISM(S): Homo sapiens 
2025-03-01 | E-MTAB-14745 | biostudies-arrayexpress
TranscriptomicsPROS1 released by lung basal cells limits inflammation in epithelial and monocytes during SARS-CoV-2 infection
The data here represent two Single-Cell experiments performed to understand the roles of PROS1 in bronchial epithelial cells and monocytes, infected by SARS-CoV-2. The CVR EXP5 contains epithelial cultures grown on Air-Liquid Interface as mock or infected by the delta variant of SARS-CoV-2 (Delta B....
ORGANISM(S): Homo sapiens 
2025-10-17 | E-MTAB-14405 | biostudies-arrayexpress
TranscriptomicsRNA-seq time-course of Calu-3 cells infected with SARS-CoV-2 early-lineage and Alpha variant viruses
Emergence of SARS-CoV-2 variants of concern (VOCs), including the globally successful Alpha (B.1.1.7) variant, suggests viral adaptation to enhance human-to-human transmission. Although much effort has focused on characterisation of spike changes, Alpha mutations outside spike likely contribute to a...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-11275 | biostudies-arrayexpress
ProteomicsCirculating ACE2-expressing Extracellular Vesicles as an Innate Antiviral Response and A Decoy Therapy to Block Broad Strains of SARS-CoV-2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)has caused the pandemic of the coronavirus induced disease 2019 (COVID-19) with 216 million cases and 4.5 million deathsas of September 2021.Thathas been exacerbated by mutated variants such as α, β, and with high infection rates and i...
ORGANISM(S): Homo Sapiens (human) 
2021-12-10 | PXD029662 | JPOST Repository
ProteomicsPeptide mapping and intact mass analysis of RBD protein from a SARS-CoV-2 omicron variant (RBDom)
RBD protein from the SARS-CoV-2 omicron variant (RBDom) was produced in Komagataella phaffii. Peptide mapping and intact mass analysis of RBDom were performed by LC/MS. Proteins were identified using BioPharma Finder software.
ORGANISM(S): Komagataella Phaffii 
2024-10-30 | PXD057342 | JPOST Repository
ProteomicsB cell epitope mapping of SARS-CoV-2 spike vaccinated rabbits
This experiment aims to profile polyclonal antibody binding profiles in serum from vaccinated animals relative to antibody function in a virus neutralization assay. Rabbits received three vaccinations with a DNA vaccine encoding the spike protein of the SARS-CoV-2 index strain. Serum samples were se...
ORGANISM(S): Oryctolagus cuniculus 
2023-08-31 | E-MTAB-13040 | biostudies-arrayexpress
ProteomicsProteotypic peptides for SARS-CoV-2 variant detection
The recent SARS-CoV-2 omicron variant presented significant challenges to the global effort to counter the pandemic. SARS-CoV-2 is predicted to remain prevalent in the coming months, making the ability to identify SARS-CoV-2 variants imperative in understanding and controlling the pandemic. The pred...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-10-12 | PXD033777 | Pride
Sars-cov-2 Lcms 
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