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TranscriptomicsGenes affected by manipulation of LIMT, a novel metastasis inhibiting lncRNA is suppressed by EGF and down-regulated in aggressive breast cancer
The long non coding RNA LIMT was found in our study to inhibit cellular migration in vitro and to inhibit colonization of mammary tumorigenic cells in lungs of mice in vivo. In order to uncover the mechanism enabling these tumor suppressive functions of LIMT the expression of this lncRNA was knocked...
ORGANISM(S): Homo sapiens 
2017-07-27 | E-MTAB-4821 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by microarray of lncRNA affected by EGF stimulation of MCF10A cells
Using basal‐like untransformed cells, MCF10A, as a model system, data from our laboratory showed that both mRNAs and microRNAs exhibit dynamic changes in expression following EGF stimulation (Amit et al, 2007; Avraham et al, 2010; Kostler et al, 2013). We further demonstrated that the inducible mRNA...
ORGANISM(S): Homo sapiens 
2017-07-27 | E-MTAB-4822 | biostudies-arrayexpress
ProteomicsA sequence-specific RNA acetylation catalyst
N4-acetylcytidine (ac4C) is a ubiquitous RNA modification incorporated by cytidine acetyltransferase enzymes. Here, we report the biochemical characterization of Thermococcus kodakarensis Nat10 (TkNat10), an RNA acetyltransferase involved in archaeal thermotolerance. We demonstrate that TkNat10's ca...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-10-14 | MSV000096084 | MassIVE
TranscriptomicsmitoRibo-seq and RNA-seq of parental and MRM2 knockout HEK 293T Flp-In T-REx cells
Methyltransferase MRM2 methylates the 2’-hydroxyl group of ribonucleotide U1369 of human 16S mt-rRNA. Mutations in MRM2 have been implicated in human mitochondrial-related disease. This study investigates the role of MRM2 in the biogenesis and function of human mitochondrial ribosomes. Absence of MR...
ORGANISM(S): Homo sapiens 
2021-12-17 | E-MTAB-11292 | biostudies-arrayexpress
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