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ModelsPhosphatase activities on PI(3,4,5)P3 and PI(3,4)P2
Phosphatase activities on PI(3,4,5)P3 and PI(3,4)P2 This model describes the action of various phosphatases on PI(3,4,5)P3 and PI(3,4)P2, in response to a stimulation by EGF. It contains boolean switches to simulate knock-down and knock-out of phosphatases as well as inhibition of PI3 kinase. ...
MODEL1704190000 | BioModels
TranscriptomicsMethylation status in human sperm
Genomic imprinting describes the expression of a subset of mammalian genes from one parental chromosome. The parent-of-origin specific expression of imprinted genes relies on DNA methylation of CpG-dinucleotides at differentially methylated regions (DMRs) during gametogenesis. We identified the pate...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-18178 | biostudies-arrayexpress
TranscriptomicsMethylation status in AG- and PG-derived cells and sperm
Genomic imprinting describes the expression of a subset of mammalian genes from one parental chromosome. The parent-of-origin specific expression of imprinted genes relies on DNA methylation of CpG-dinucleotides at differentially methylated regions (DMRs) during gametogenesis. We identified the pate...
ORGANISM(S): Mus musculus 
2010-05-04 | E-GEOD-18126 | biostudies-arrayexpress
TranscriptomicsHuman Subperitoneal Fibroblasts and Cancer Cell Interaction Creates Microenvironment Enhancing Tumor Progression and Metastasis
Fibroblasts isolated from human colon submucosal and subperitoneal layer were stimulated by colon cancer cell line (DLD-1) cultured medium. Peritoneal invasion in colon cancer is an important prognostic factor, and the fibrosis with α-SMA was a significant pathological feature of the cancer microenv...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-53059 | biostudies-arrayexpress
TranscriptomicsAnalysis of small RNAs in piRNA pathway mutant mouse testes
Piwi-interacting RNAs are 25-32 nt small RNAs bound to Piwi proteins. To know the steps where factors involved in the piRNA biogenesis (MILI, MIWI2, ZUC (MitoPLD), MVH) work, we sequenced small RNAs from mutant mouse testes and analyzed piRNAs. Examination of small RNAs in testes of mutant mouse
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20327 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity
Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear. GATA3, a master regulator of Th2 cell differentiation...
ORGANISM(S): Mus musculus 
2013-04-19 | E-GEOD-46185 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of human fibroblasts from whole body
Fibroblasts are the principal stromal cells that exist in whole organs and play vital roles in many biological processes. Although the functional diversity of fibroblasts has been estimated, a comprehensive analysis of fibroblasts from the whole body has not been performed and their phenotypical div...
ORGANISM(S): Homo sapiens 
2014-11-26 | E-GEOD-63626 | biostudies-arrayexpress
UnknownArms race between anti-silencing and RdDM in noncoding regions of transposable elements
Not available
S-SCDT-10_15252-EMBR_202256678 | biostudies-other
UnknownIron loss triggers mitophagy through induction of mitochondrial ferritin
Not available
S-SCDT-EMBOR-2020-50202V1 | biostudies-other
ProteomicsProtein expression in heated rat lens using shotgun proteomics
Previous studies have reported that a strong correlation between the estimated cumulative thermal exposure in the crystalline lens and the incidence of nuclear cataracts; however, the precise relationship between temperature and cataracts remains to be fully elucidated. In the present study, the sho...
ORGANISM(S): Rattus 
2024-09-22 | PXD056067 | JPOST Repository
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