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ModelsBertram2007_IsletCell_Oscillations
This is the model described in the article: Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets. Bertram R, Satin LS, Pedersen MG, Luciani DS, Sherman A. Biophys J. 2007 Mar 1;92(5):1544-55. Pubmed ...
2024-09-02 | BIOMD0000000376 | BioModels
MetabolomicsIAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers imp...
2020-04-17 | MTBLS951 | MetaboLights
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