Sort   by:  
 Page size 
TranscriptomicsWhole genome gene expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells
HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted c...
ORGANISM(S): Homo sapiens 
2012-02-23 | E-GEOD-33615 | biostudies-arrayexpress
GenomicsThe enhancer and promoter landscape of human regulatory and conventional T cell subpopulations
CD4+CD25+FOXP3+ human regulatory T cells (Treg) are essential for self-tolerance and immune homeostasis. Here, we generated genome-wide maps of poised and active enhancer elements marked by histone H3 lysine 4 monomethylation and histone H3 lysine 27 acetylation for CD4+CD25highCD45RA+ naive and CD4...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-43119 | biostudies-arrayexpress
ProteomicsArabidopsis cell LC-MSMS - Proteomics analysis reveals a highly heterogeneous proteasome composition and the post-translational regulation of peptidase activity under pathogen signaling in plants
26S proteasome was affinity-purified with anti-FLAG beads and separated by 2-DE method. Each spot was cut and digested by Trypsin enzyme, which finaly applied for LC-MS/MS nalysis using a LTQ-Orbitrap XL (Thermo Scientific). The obtained spectra were compared against 35,386 sequences in The Arabidop...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2014-07-28 | PXD000417 | Pride
26sp 
TranscriptomicsAffymetrix SNP array data for acute T-cell leukemia/lymphoma (ATL)
SNP array analysis was performed using 168 ATL specimens. To obtain genotypes and intensities for each SNP, Affymetrix 250K SNP arrays were performed for 168 ATL samples.
ORGANISM(S): Homo sapiens 
2012-02-23 | E-GEOD-33602 | biostudies-arrayexpress
UnknownA clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy.
Not available
S-EPMC7814014 | biostudies-literature
TranscriptomicsMerck Ad5/HIV induces broad innate immune activation that predicts CD8+ T-cell responses but is attenuated by preexisting Ad5 immunity.
This SuperSeries is composed of the following subset Series: GSE22768: Systems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vivo analysis GSE22769: Systems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immun...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-22822 | biostudies-arrayexpress
TranscriptomicsRNA-seq on human regulaotry T cells before and after TCR stimulation
Human FOXP3+ regulatory T cells were isolated as CD4+CD25+CD127- population from PBMCs. Cells were stimulated with TCR stimulation with the presence of rhIL-2.
ORGANISM(S): Homo sapiens 
2025-06-01 | E-MTAB-14707 | biostudies-arrayexpress
UnknownEffective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells.
Not available
S-EPMC5834292 | biostudies-literature
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
TranscriptomicsRNA-seq on human naive and memory regulaotry T cells before and after TCR stimulation.
Human FOXP3+ regulatory T cells were isolated as CD4+CD25+CD127- population from PBMCs. Cells were stimulated with TCR stimulation with the presence of rhIL-2. Naive cells were CD45RA+ and memory cells were CD45RA-.
ORGANISM(S): Homo sapiens 
2026-02-01 | E-MTAB-16435 | biostudies-arrayexpress
Sort   by:  
 Page size