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ProteomicsAn AMP-activated protein kinase-PGC-1α axis mediates metabolic plasticity in glioblastoma
Glioblastoma, the most frequent primary malignant brain tumor in adults, is characterized by profound yet dynamic hypoxia and nutrient depletion. To sustain survival and proliferation, tumor cells are compelled to acquire metabolic plasticity with the induction of adaptive metabolic programs. We hav...
ORGANISM(S): Homo sapiens (Human) 
2025-01-19 | PXD046679 | Pride
Amp-kinase Pgc-1α Ppargc1a Hypoxia Glioblastoma Metabolic plasticity Tumor microenvironment 
UnknownD-xylose degradation pathway in the halophilic archaeon Haloferax volcanii.
Not available
S-EPMC2785657 | biostudies-literature
ProteomicsAMP-kinase mediates adaptation of glioblastoma cells to conditions of the tumour microenvironment
Proteomic analysis of LNT-299 cells.In this experimental study, we investigated the role of the AMPK-mediated stress response in human GB cells. Mimicking the conditions of the tumour microenvironment we deprived GB cells of glucose and oxygen to characterize metabolic effects and to delineate the r...
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD055976 | Pride
Glioblastoma Tmt Ampk Lc-ms/ms 
ProteomicsProteome of senescent human lung fibroblasts and Panc-1 cells
Proteomic analysis of proliferating and senescent normal healthy lung fibroblasts (NHLFs) and Panc-1 cells. Senescence was induced using 5 uM Palbociclib for 6 days. Cells were lysed in SDS lysis buffer (2% SDS in 100 mM TEAB), boiled (15 min, 95 °C, 500 rpm) and sonicated in a sonication bath (10 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-28 | MSV000090607 | MassIVE
UnknownStringent Selection of Knobby Plasmodium falciparum-Infected Erythrocytes during Cytoadhesion at Febrile Temperature.
Not available
S-EPMC7074740 | biostudies-literature
GenomicsChromatin maps of the Drosophila melanogaster TrxG protein Ash1 and FSH
Trithorax group (TrxG) proteins counteract Polycomb silencing by an as yet uncharacterized mechanism. A well-known member of the TrxG is the histone methyltransferase Absent, Small, or Homeotic discs 1 (ASH1). In Drosophila ASH1 is needed for the maintenance of Hox gene expression throughout develop...
ORGANISM(S): Drosophila melanogaster 
2013-06-30 | E-GEOD-30820 | biostudies-arrayexpress
GenomicsGeneration of chromatin maps for ASH1 and FSH applying ChIP-seq
see Super Series Summary Cross-linked chromatin derived from Drosophila S2-DRSC cells was immunoprecipitated using antibodies targeting ASH1 and FSH. Precipitated chromatin was sequenced applying Illumina sequencing.
ORGANISM(S): Drosophila melanogaster 
2013-02-06 | E-GEOD-36404 | biostudies-arrayexpress
UnknownDevelopment of a high-resolution NGS-based HLA-typing and analysis pipeline.
Not available
S-EPMC4477639 | biostudies-literature
GenomicsThe BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila
Background: The question of how cells re-establish gene expression states after cell division is still poorly understood. Genetic and molecular analyses have indicated that Trithorax group (TrxG) proteins are critical for the long-term maintenance of active gene expression states in many organisms. ...
ORGANISM(S): Drosophila melanogaster 
2013-02-06 | E-GEOD-36450 | biostudies-arrayexpress
MetabolomicsGenomic and lipidomic actions of nandrolone on detached rotator cuff muscle in sheep
Reversal of fatty infiltration of pennate rotator cuff muscle after tendon release is hitherto impossible. The administration of nandrolone starting at the time of tendon release prevents the increase in fat content, but does not revert established fatty infiltration. We hypothesised that tendon rel...
2017-07-14 | MTBLS322 | MetaboLights
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