Sort   by:  
 Page size 
TranscriptomicsGlobal DNA methylation profiling of CD4+ T cells from patients with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic-relapsing autoimmune disease of incompletely understood etiology. Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. To understand the extent and nature of dysregulated DNA methylation in lupus T cells, we perfor...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-27895 | biostudies-arrayexpress
UnknownConfirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus.

Objective

Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was und...
S-EPMC3028384 | biostudies-literature
UnknownA putative functional variant within the UBAC2 gene is associated with increased risk of Behcet's disease.

Objective

Using a genome-wide association scan and DNA pooling, we previously identified 5 novel genetic susceptibility loci for Behçet's disease. We undertook this study to establish the genetic effect within the UBAC2 gene, in the course of which we replicated this genetic association and ...
S-EPMC3205238 | biostudies-literature
Sort   by:  
 Page size