Global DNA methylation profiling of CD4+ T cells from patients with systemic lupus erythematosus

ABSTRACT: Systemic lupus erythematosus (SLE) is a chronic-relapsing autoimmune disease of incompletely understood etiology. Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. To understand the extent and nature of dysregulated DNA methylation in lupus T cells, we performed a genome-wide DNA methylation study in CD4+ T cells from 12 lupus patients and 12 normal healthy controls. Cytosine methylation was quantified in 27,578 CG pairs located within the promoter regions of 14,495 genes. We identified 236 hypomethylated and 105 hypermethylated CG sites in lupus CD4+ T cells compared to normal controls, consistent with a global hypomethylation in lupus T cells. Further analysis identified hypomethylation in genes involved in connective tissue development including

ORGANISM(S): Homo sapiens

SUBMITTER: Mikhail Dozmorov 

PROVIDER: E-GEOD-27895 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress