DNA methylation profiling of human adrenocortical tumors (ACTs)

ABSTRACT: A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Transcriptome analysis led to the unsupervised classification of carcinomas in two groups, associated with different outcomes {de Reynies, 2009 ; Giordano, 2009}. Subsequently, we have shown that unsupervised clustering further classified the tumors of the poor prognosis group in three different subgroups, two of them harbouring a cardinal molecular alteration {Ragazzon, 2010}. One is associated with p53 inactivation, the second with ?-catenin activation. No molecular defect has been identified in the third group so far. The aim is to describe the genome-wide methylome of adrenocortical tumors, and to assess the link with previously established molecular classifica

ORGANISM(S): Homo sapiens

DISEASE(S): Adrenocortical Adenoma

SUBMITTER: Olivia Barreau 

PROVIDER: E-MTAB-815 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress