Mesothelioma integrative genomics: DNA methylation

ABSTRACT: Integrated profiling of somatic molecular alterations present in tumors is necessary to further our understanding of the tumorigenic process. We investigated the potential relationships between gene copy number alterations and DNA methylation profiles in a case series of pleural mesotheliomas (n=23). Gene copy number (CN) alterations profiled with 500K SNP arrays and DNA methylation measured at over 750 cancer-related genes with methylation bead-arrays were examined concomitantly. Considering each probed locus, there were no instances of significantly correlated CN alteration and methylation (no loci with Q < 0.05) and averaging loci over their associated genes revealed only two genes with significantly correlated CN and methylation alterations (Q < 0.04). In contrast to the lack of discre

ORGANISM(S): Homo sapiens

SUBMITTER: Brock Christensen 

PROVIDER: E-GEOD-20989 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress