Lung adenocarcinoma and mesothelioma DNA methylation

ABSTRACT: Pathologic differentiation of tissue of origin in tumors found in the lung can be challenging, with differentiation of mesothelioma and lung adenocarcinoma emblematic of this problem. Indeed, proper classification is essential for determination of treatment regimen for these diseases, making accurate and early diagnosis critical. Here we investigate the potential of epigenetic profiles of lung adenocarcinoma, mesothelioma, and non-malignant pulmonary tissues (n=285) as differentiation markers in an analysis of DNA methylation at 1413 autosomal CpG loci associated with 773 cancer-related genes. Using an unsupervised recursively-partitioned mixture modeling technique for all samples, the derived methylation profile classes were significantly associated with sample type (P < 0.0001). In a sim

ORGANISM(S): Homo sapiens

SUBMITTER: Brock Christensen 

PROVIDER: E-GEOD-16559 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress