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TranscriptomicsHigh weight differences between donor and recipient affect early kidney graft function -a role for IL-6 signaling
The frequency of delayed function of kidney transplants varies greatly and is associated with the quality of graft, donor age, and the duration of cold ischemia time. Body weight differences between donor and recipient can affect primary graft function. The underlying mechanism is poorly understood....
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-15813 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human regulatory T cells and effector T cells cultured at standard 37C temperature and in mild hypothermia (33C).
Regulatory T cells (Tregs) play crucial role in maintenance of peripheral tolerance. Numerous clinical trials confirmed safety and efficacy of Treg treatment of for deleterious immune responses. However, Tregs lose their characteristic phenotype and suppressive potential during expansion ex vivo. In...
ORGANISM(S): Homo sapiens 
2017-10-04 | E-MTAB-5322 | biostudies-arrayexpress
TranscriptomicsMechanisms and rescue strategies of Calcineurin inhibitor mediated tolerance abrogation
To ensure safety tolerance induction protocols are accompanied by conventional immunosuppressive drugs IS. But IS such as calcineurin inhibitors CNI can interfere with tolerance induction. We investigated the effect of an additional CNI treatment on anti-CD4 mAb-induced tolerance induction upon rat ...
ORGANISM(S): Rattus norvegicus 
2013-09-01 | E-GEOD-40454 | biostudies-arrayexpress
TranscriptomicsIndices of Tolerance (IOT): Cross-platform biomarkers that identify kidney transplant tolerance
Being able to identify patients in whom immunological tolerance has been established or is developing would allow an individually tailored approach to post-transplant management of kidney allograft recipients. Ex vivo immunological monitoring was performed on samples from five groups of European ren...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-14655 | biostudies-arrayexpress
TranscriptomicsThe dependence on NFAT levels discriminates conventional T cells from Foxp3 expressing regulatory cells
In this study, we used microarrays to investigate the gene expression program in conventional T cells, nTreg and conventional T cells treated with TGFbeta (iTreg) from wild-type mice and and mice having NFAT1/NFAT2 double-deficient (DKO) T cells. CD4+CD25- and CD4+CD25+ T cells were isolated by MACS...
ORGANISM(S): Mus musculus 
2012-10-15 | E-MEXP-3687 | biostudies-arrayexpress
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