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SC-beta vs SC-EC +/- IFN-G
SC-beta Cell in vivo Maturation
RNA Seq of IAPP expressing SC-β cells
Infection of SC-beta cells with coxsackievirus B4 (CVB)
The goal of this study was to identify transcriptional changes in SC-beta and SC-endothelial cells pre and post IFN-gamma stimulation. Specifically, to characterize the differential expression of immune cell ligands in these cells with respect to a partial inflammatory stimulus.
ORGANISM(S): Homo sapiens 
2022-12-23 | GSE200021 | GEO
Stem cell-derived β (SC-β) cells are an emerging regenerative therapy to compensate for loss of functional β cell mass in diabetes. Glucose-stimulated insulin secretion in SC-β cells is variable in vitro but stabilizes after transplantation and maturation under the kidney capsule of mice. We identif...
ORGANISM(S): Homo sapiens 
2019-08-19 | GSE135944 | GEO
Islet transplantation for treatment of diabetes is limited by availability of donor islets and requirements for immunosuppression. Stem cell-derived islets might circumvent these issues. SC-islets effectively control glucose metabolism post transplantation, but do not yet achieve full function in vi...
ORGANISM(S): Homo sapiens 
2024-04-15 | GSE263366 | GEO
SC-beta cells were infected with CVB and collected over a time course.
ORGANISM(S): Homo sapiens 
2020-02-12 | GSE145074 | GEO
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