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ProteomicsLiver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing factor RNA-binding Fox protein-2 (RBFOX2) in mainta...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-28 | PXD036976 | Pride
Mouse Cholesterol Liver Splicing 
GenomicsChromatin Capture Identifies SCARB1-LAG3 Proinflammatory Cardiovascular Disease Gene Networks
Chromatin Capture Identifies SCARB1-LAG3 Proinflammatory Cardiovascular Disease Gene Networks
PRJNA434469 | ENA
GenomicsLactate promotes cholesterol uptake by facilitating SCARB1 expression through histone H3K18 lactylation
Lactate promotes cholesterol uptake by facilitating SCARB1 expression through histone H3K18 lactylation
PRJNA1330274 | ENA
GenomicsLactate-mediated cholesterol uptake promotes liver cancer progression through the SCARB1-autophagy axis
Lactate-mediated cholesterol uptake promotes liver cancer progression through the SCARB1-autophagy axis
PRJNA1403378 | ENA
GenomicsChromatin Capture Identifies SCARB1-LAG3 Proinflammatory Cardiovascular Disease Gene Networks [4C-Seq]
Chromatin Capture Identifies SCARB1-LAG3 Proinflammatory Cardiovascular Disease Gene Networks [4C-Seq]
PRJNA434463 | ENA
TranscriptomicsChromatin Capture Identifies SCARB1-LAG3 Proinflammatory Cardiovascular Disease Gene Networks
Increased high density lipoprotein (HDL) cholesterol levels have been associated with mutations in the cholesterol efflux receptor gene SCARB1, contributing to coronary artery disease (CAD). Using chromatin capture techniques (4C-Seq and HiC), ChIP-Seq and RNA-Seq, we identified a potential mechanis...
ORGANISM(S): Homo sapiens 
2019-10-04 | GSE110761 | GEO
UnknownSCARB1 downregulation in adrenal insufficiency with Allgrove syndrome.
Not available
S-EPMC10278336 | biostudies-literature
UnknownSCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells.
Not available
S-EPMC12627352 | biostudies-literature
TranscriptomicsLactate promotes cholesterol uptake by facilitating SCARB1 expression through histone H3K18 lactylation
Metabolic reprogramming supports the proliferation of cancer cells under hypoxic stress, including enhanced glycolysis and altered fatty acid metabolism. However, the mechanism underlying its regulation of cholesterol metabolism remains incompletely understood. Here, we show that lactate-induced cho...
ORGANISM(S): Homo sapiens 
2025-09-18 | GSE308360 | GEO
UnknownInhibition of Scarb1 on Endothelial Cells Attenuates Pressure Overload-Induced Heart Failure Progression.
Not available
S-EPMC12665495 | biostudies-literature
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