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MetabolomicsFeasibility of detecting AC and SCC using UPLC-HRMS based tissue metabolomics
Not available
ORGANISM(S): Homo sapiens 
ST002120 | MetabolomicsWorkbench
TranscriptomicsmiRNA expression profiling in squamous cell carcinoma (SCC)
Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. We recently identified the developmental transcription factor Grhl3 as a potent tumor suppressor of SCC, and demonstrated that targeting of Grhl3 by a miR-21-dependent proto-oncogenic network unde...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-32868 | biostudies-arrayexpress
TranscriptomicsMEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma (SCC)
Genomic analyses of SCC have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single agent or alongside other chemotherapeutic drugs or radiotherapy; however,...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-66549 | biostudies-arrayexpress
TranscriptomicsKGF effects on cutaneous SCC cells
Keratinocyte growth factor (KGF, fibroblast growth factor-7) is a fibroblast-derived mitogen, which stimulates proliferation of epithelial cells. The expression of KGF by dermal fibroblasts is induced following injury and it promotes wound repair. However, the role of KGF in cutaneous carcinogenesis...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-34652 | biostudies-arrayexpress
TranscriptomicsAltered Epigenetic Regulation of Homeobox Genes in Human Oral Squamous Cell Carcinoma Cells
To gain insight into the molecular changes during OSCC carcinogenesis, we performed unbiased, whole genome deep sequencing (RNA-seq) using RNA isolated from cultured, human TERT-immortalized, non-tumorigenic OKF6-TERT1R and OSCC SCC-9 cells. OKF6-TERT1R cells and SCC-9 cells were plated in 10 cm2 t...
ORGANISM(S): Homo sapiens 
2013-10-19 | E-GEOD-51415 | biostudies-arrayexpress
TranscriptomicsETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (RNA-Seq I)
After characterizing super-enhancer-associated chromatin dynamics accompanied by malignant progression of skin stem cells, we show that ETS family members auto-regulate themselves and a cohort of cancer-associated super-enhancer transcription factors which together are essential for tumor maintenanc...
ORGANISM(S): Mus musculus 
2015-11-22 | E-GEOD-72146 | biostudies-arrayexpress
GenomicsST779-MRSA with a pseudo SCCmec-SCC-SCC (CRISPR)
WHole genome sequencing of a ST779-MRSA isolate identified a novel composite SCC element we have termed a pseudo SCCmec-SCC-SCC(CRISPR) element
PRJEB224 | ENA
TranscriptomicsArrayCGH mapping of the recurrent 3q26.3-q27 amplifications in lung Squamous Cell Carcinoma (SCC)
To prospectively identify new oncogenes implicated in lung Squamous Cell Carcinoma pathogenesis, we investigated chromosome 3 aberrations in advanced tumours using arrayCGH. Chromosome 3 aberrations are indeed among the most frequent alterations in lung SCC and correlate with SCC patient's poor prog...
ORGANISM(S): Homo sapiens 
2010-02-09 | E-GEOD-15079 | biostudies-arrayexpress
TranscriptomicsFGFR2 Signaling Underlies p63 Oncogenic Function in Squamous Cell Carcinoma
This study was designed to examine the requirement for the p63 transcription factor in Squamous Cell Carcinoma (SCC) tumor maintenance in an in vivo murine system. A tamoxifen-inducible Keratin 14-driven Cre recombinase transgene was used to conditionally excise p63 in advanced murine SCC tumors. ...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-45929 | biostudies-arrayexpress
Transcriptomicsdelta-Np63 loss of function study in the HNSCC cell line UT-SCC-74A
delta-Np63 is highly expressed in squamous cell carcinoma of the head and neck (HNSCC). To evaluate its function in HNSCC we depleted delta-Np63 by siRNAs in the HNSCC cell line UT-SCC-74A. The transcriptome was analysed by cDNA microarray.
ORGANISM(S): Homo sapiens 
2016-01-14 | E-MTAB-3670 | biostudies-arrayexpress
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