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ProteomicsBioID screen for NRF3 interactors in SCC13 and HaCaT cells
We identified the transcription factor NRF3 as an important tumor-suppressing protein in the skin. To gain insight into the mechanisms of action of NRF3 in keratinocytes, we searched for NRF3 interactors in the SCC13 skin cancer and the immortalized non-tumorigenic HaCaT cell line using BioID intera...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD043305 | Pride
Hacat cells Q-exactive hf Nrf3 Scc13 cells Bioid 
GenomicsDifferentially expressed genes in SCC13 NRF3-KO cells and SCC13 cells that re-express endogenous concentrations of recombinant NRF3
Differentially expressed genes in SCC13 NRF3-KO cells and SCC13 cells that re-express endogenous concentrations of recombinant NRF3
PRJNA941808 | ENA
TranscriptomicsDifferentially expressed genes in SCC13 NRF3-KO cells and SCC13 cells that re-express endogenous concentrations of recombinant NRF3
We identified a tumor-suppressing function of NRF3 in skin cancer. To determine the underlying mechanism of action we wanted to compare the transcriptome of SCC13 NRF3-KO cells and SCC13 cells that re-express endogenous concentrations of recombinant NRF3.
ORGANISM(S): Homo sapiens 
2023-10-09 | GSE226798 | GEO
GenomicsAnalysis of genes bound by ULK3 and of H3K27 histone modification plus/minus ULK3 silencing in SCC13 cells
Analysis of genes bound by ULK3 and of H3K27 histone modification plus/minus ULK3 silencing in SCC13 cells
PRJNA762354 | ENA
GenomicsULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis [shULK3 SCC13]
ULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis [shULK3 SCC13]
PRJNA759139 | ENA
TranscriptomicsDifferential gene expression profile of SCC13 tumor cells after TLR4 overexpression and LPS treatment
BACKGROUND & AIMS: TLR4 is an innate immune receptor with expression in human skin, keratinocytes as well as squamous cell carcinoma (SCC) of the skin. In the present study we investigate the role of TLR4 as a negative regulator of keratinocyte proliferation. We present here that the expression of T...
ORGANISM(S): Homo sapiens 
2016-11-16 | GSE89856 | GEO
TranscriptomicsULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis [shULK3 SCC13]
Transcriptomic profiling of human squamous cell carcinoma cells SCC13 infected with three ULK3 silencing lentivirus versus control virus
ORGANISM(S): Homo sapiens 
2022-10-10 | GSE183085 | GEO
GenomicsAnalysis of genes bound by ULK3 and of H3K27 histone modification plus/minus ULK3 silencing in SCC13 cells
We report high-throughput profiling of genes bound by ULK3 and of H3K27 histone modification plus/minus ULK3 silencing in squamous cell carcinoma SCC13 cells .
ORGANISM(S): Homo sapiens 
2022-10-10 | GSE183933 | GEO
GenomicsRNA sequencing after HOPX knockdown in human squamous cell carcinoma cell line SCC13
RNA sequencing after HOPX knockdown in human squamous cell carcinoma cell line SCC13
PRJNA606791 | ENA
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
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