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TranscriptomicsTranscription profiling of human sensitive and resistant tumours identify gene expression patterns in primary breast-cancer specimens that might predict response to taxanes.
These patients proved resistant to docetaxel treatment, exhibiting residual tumor of 25% or greater remaining volume.
ORGANISM(S): Homo sapiens 
2007-10-04 | E-GEOD-349 | biostudies-arrayexpress
TranscriptomicsA Gene Expression Network Model of Type 2 Diabetes Links Cell Cycle
Insulin resistance is necessary but not sufficient for the development of type 2 diabetes. Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by increasing insulin production through an expansion of beta-cell mass or increased insulin secretion. Communication betwe...
ORGANISM(S): Mus musculus 
2008-03-14 | E-GEOD-10785 | biostudies-arrayexpress
TranscriptomicsGene Bionetwork Analysis of Ovarian Primordial Follicle Development
Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. A systems biology approach was used to identify regulatory gene networks essential for primordial follicle development. Transcriptional responses to eight different growth...
ORGANISM(S): Rattus norvegicus 
2010-06-13 | E-GEOD-20324 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver, kidney and brain from male and female Zebra Finches
Each array hybridization involved one male sample hybridized in competition to one female sample. For each hybridization one sample was labeled with Cy5 and the other with Cy3. Half of the male samples were labeled with Cy5 and rest with Cy3. Each hybridization was tissue-specific (i.e., hybridiz...
ORGANISM(S): Taeniopygia guttata 
2007-02-15 | E-MEXP-543 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Muscle tissue from (C57BL/6J X C3H/HeJ)F2 mice on ApoE null backgrounds
The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age. Muscle from 319 F2 female and male mice (animals fed a high fat "Western" diet from 8-24 weeks of age.) derived from C57BL/6J and C3H/...
ORGANISM(S): Mus musculus 
2006-07-06 | E-GEOD-3088 | biostudies-arrayexpress
TranscriptomicsExpression profiling of brain tissue from (C57BL/6J X C3H/HeJ)F2 mice on ApoE null backgrounds
The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age. Brain from 249 F2 female and male mice (animals fed a high fat "Western" diet from 8-24 weeks of age.) derived from C57BL/6J and C3H/H...
ORGANISM(S): Mus musculus 
2006-07-06 | E-GEOD-3087 | biostudies-arrayexpress
TranscriptomicsMolecular mechanisms underlying the metabolic changes induced by the Pro12Ala PPARγ2 variant in mice
The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARγ2) variant Pro12Ala in human populations has been widely debated. We demonstrate using a Pro12Ala knock-in model that on chow Ala/Ala mice are leaner, have improved insulin sensitivity and plasma lip...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-13305 | biostudies-arrayexpress
TranscriptomicsA functional genomics predictive network model identifies regulators of inflammatory bowel disease: Microarray Analysis of Human Blood and Intestinal Biopsy Samples from a Phase 2b, Double-blind, Placebo-controlled Study of Ustekinumab in Crohn's Disease
Microarray Analysis of Human Whole Blood and Intestinal Biopsy Samples from a Phase 2b, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Crohn’s Disease 329 Crohn's biopsies from multiple regions in the intestine of 87 anti TNFa refractory patients an...
ORGANISM(S): Homo sapiens 
2017-07-07 | E-GEOD-100833 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Adipose tissue from (C57BL/6J X C3H/HeJ)F2 mice on ApoE null backgrounds
The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age. Adipose from 295 F2 female and male mice (animals fed a high fat "Western" diet from 8-24 weeks of age.) derived from C57BL/6J and C3H...
ORGANISM(S): Mus musculus 
2006-07-07 | E-GEOD-3086 | biostudies-arrayexpress
TranscriptomicsProfiling of hypothalamus tissue from the F2 M16xICR mouse cross.
We profiled gene expression in hypothalamus tissue from F2 progeny from a cross between the outbred M16 (selectively bred for rapid weight gain) and ICR (control) mouse strains. We developed a framework for reconstructing tissue-to-tissue coexpression networks between genes in hypothalamus, liver or...
ORGANISM(S): Mus musculus 
2010-06-22 | E-GEOD-13745 | biostudies-arrayexpress
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