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ProteomicsGT-stabiligase N-terminomics technology for capturing proteolytic modifications on human cell surfaces
Here we introduce a stabiligase technology that directly identifies neo-proteolytic epitopeson the cell surface of human cells using a glycan-tethered, engineered peptide ligase.
ORGANISM(S): Homo sapiens (Human) 
2023-06-23 | PXD033811 | Pride
Subtiligase protein engineering N-terminomics Proteolysis 
ProteomicsLow Density Lipoprotein Receptor Targeting Chimeras for Membrane Protein Degradation and Enhanced Drug Delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells, among which antibody-drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depend on efficient lysosomal trafficking for activity. However, many tumor antigens exhibit poor interna...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD064642 | Pride
Antibody based degradation 
ProteomicsHypoxia induces extensive protein and proteolytic remodeling of the cell surface in pancreatic adenocarcinoma (PDAC) cell lines
A study on the cell surface modifications that occur on pancreatic epithelial cells in a hypoxic tumor microenvironment.
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD057350 | Pride
Pancreatic cancer 
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