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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
ProteomicsThe UGT2B17 metabolic pathway as a key determinant of liver homeostasis: evidence from the hepatic proteome of individuals naturally deficient in UGT2B17
One of the most crucial pathways involved in the metabolism and detoxification of drugs and endobiotics is the glucuronidation process, primarily occurring in the liver. This pathway is catalyzed by glycosyltransferases comprising 22 enzymes such as UGT2B17, which is entirely absent in a large propo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095873 | MassIVE
GenomicsDAC for Tuebingen-Stuttgart cohort
Data Access Committee EGAC00001000317
EGAC00001000317 | EGA
GenomicsRCC_HTA2.0_Reustle2020
GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) related to Reustle et al, Genome Med 12:2020 32. Preprocessing of microarray data was performed using Robust Multi-array Average (RMA).
EGAD00010002323 | EGA
GenomicsRCC_HTA2.0_Buettner2022
GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) related to Buettner et al, Genome Med 2022. Microarrays were normalized individually using the SCAN method from the R package SCAN.UPC (version 2.26.0, R version 3.6.1). Probe sets were summarized on the Entrez GeneID level using the annota...
EGAD00010002353 | EGA
GenomicsRCC_HTA2.0_Reustle2022
GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) related to Reustle et al., Clin Transl Med 12:2022 e883. Microarrays were normalized individually using the SCAN method from the R package SCAN.UPC (version 2.26.0, R version 3.6.1). Probe sets were summarized on the Entrez GeneID level usi...
EGAD00010002352 | EGA
GenomicsAffymetrix_miRNA4.0
Primary renal cell carcinoma (RCC) by Affymetrix GeneChip miRNA 4.0
EGAD00010001564 | EGA
GenomicsPDX_HTA2.0_Guergen2022
GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) and RCC metastases related to Guergen et al, Front Oncol 12:2022 889789. Microarrays were normalized individually using the SCAN method from the R package SCAN.UPC (version 2.34.0). Probe sets were summarized on the Entrez GeneID level usin...
EGAD00010002392 | EGA
GenomicsAffymetrix_HTA2.0
Primary renal cell carcinoma (RCC) and RCC metastases by Affymetrix GeneChip HTA 2.0
EGAD00010001589 | EGA
GenomicsIllumina_450K
Primary renal cell carcinoma (RCC), RCC metastases and cell lines by Illumina 450K
EGAD00010001001 | EGA
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