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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
UnknownThermostable lipases from the extreme thermophilic anaerobic bacteria Thermoanaerobacter thermohydrosulfuricus SOL1 and Caldanaerobacter subterraneus subsp. tengcongensis.
Not available
S-EPMC2757599 | biostudies-literature
UnknownVentricular global function index is associated with clinical outcomes in pediatric pulmonary hypertension
Not available
S-EPMC10316558 | biostudies-literature
MetabolomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells (NMR assay)
Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival an...
2015-07-01 | MTBLS102 | MetaboLights
UnknownAdult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis.
Not available
S-EPMC9975768 | biostudies-literature
Proteomics• SURF2 is a new key player in nucleolar stress response through the regulation of 5S RNP/MDM2/p53 axis.
Cancer cells are addicted to strong ribosome production to sustain their proliferation rate. Many chemotherapies impede ribosome production which is perceived by cells as "nucleolar stress" (NS), triggering TP53-dependent and independent response pathways leading to cell cycle arrest and/or apoptosi...
ORGANISM(S): Homo sapiens (Human) 
2024-09-30 | PXD047905 | Pride
Cancer Ribosome Nucleolar stress Human 
UnknownClustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study.
Not available
S-EPMC9327174 | biostudies-literature
ProteomicsA druggable signaling hub of choroid plexus immune-secretory function
The choroid plexus (ChP) secretes a half-liter of cerebrospinal fluid (CSF) per day into the cerebral ventricular system and gates immune cell entry into the brain as the blood-CSF barrier. Acquired hydrocephalus, characterized by ventriculomegaly from CSF accumulation, is caused by both brain infec...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-02-20 | PXD030678 | Pride
Hydrocephalus Csf Multi-omics Choroide plexus 
ProteomicsGlutathione supports lipid abundance in vivo
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many diseases, but the requirement for GSH in adult tissues is uncle...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-03 | PXD052674 | Pride
Mouse Glutathione Gclc Liver Nrf2 
TranscriptomicsAIN-2::GFP IP of mRNAs associated with miRISC in stage sychronized C. elegans populations
AIN-2::GFP IP were used to purify miRISC from stage sychronized C.elegans populations (Egg, L1, L2, L3 and L4 stages). The mRNA composition of the IP results and the corresponding total RNA samples were analyzed by WUSTL Caenorhabditis elegans Whole Genome 23k Oligo Array. The miRISC associated mRNA...
ORGANISM(S): Caenorhabditis elegans 
2009-05-21 | E-GEOD-16208 | biostudies-arrayexpress
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