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TranscriptomicsDetermination of the transcription start sites of heterologous promoters in Actinoplanes sp. SE50/110 by 5'-end specific transcriptome sequencing
The promoter structure influences binding and clearance of RNA polymerase and therefore substantially influences expression of a gene. A promoter usually consists of a -10 and a -35-region, an extended -10-motif and A+T-rich upstream promoter elements. Most of these elements are optional, whereas th...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-26 | E-MTAB-8433 | biostudies-arrayexpress
TranscriptomicsComplex response on the level of the transcriptome by deletion of a local transcriptional repressor AmlR by RNAseq of the coding RNA
Actinoplanes sp. SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. Although maltose is an important building block of acarbose, the maltose/maltodextrin metabol...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-07 | E-MTAB-8404 | biostudies-arrayexpress
TranscriptomicsWhole track RNAseq of the deletion mutant delta cgt in Actinoplanes sp. SE50/110 during growth phase and during transition into stationary phase
Actinoplanes sp. SE50/110 (ATCC 31044) is the wild type of industrial producer strains of acarbose. Acarbose is used since the early 1990s as an inhibitor of intestinal human alpha-glucosidases in the medical treatment of type II diabetes mellitus. The small secreted protein Cgt, which consists of a...
ORGANISM(S): Actinoplanes sp. SE50/110 
2020-09-01 | E-MTAB-8432 | biostudies-arrayexpress
TranscriptomicsWhole track RNAseq of two different integrative vectors: pSET152::PrpsJ:acbC and pGUS::PrpsJ:gusA. in Actinoplanes sp. SE50/110.
The whole coding RNA of Actinoplanes sp. SE50/110 mutants containing two different integrative vectors (pSET152::PrpsJ:acbC and pGUS::PrpsJ:gusA) were sequenced. Both vectors are integrated via a phiC31 integrase (Bierman et al. 1992) into the genetic locus ACSP50_6589 (former: acpl_6602) (Gren et a...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-15 | E-MTAB-8431 | biostudies-arrayexpress
TranscriptomicsWhole track RNAseq of two vector integration mutants of Actinoplanes sp. SE50/110 (pSET152::acbB and pSETT4::acbB).
The whole coding RNA of Actinoplanes sp. SE50/110 mutants containing two different integrative vectors (pSET152::acbB and pSETT4::acbB) were sequenced. Both vectors are integrated via a phiC31 integrase (Bierman et al. 1992) into the genetic locus ACSP50_6589 (former: acpl_6602) (Gren et al. 2016). ...
ORGANISM(S): Actinoplanes sp. SE50/110 
2020-05-30 | E-MTAB-8967 | biostudies-arrayexpress
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