Sort   by:  
 Page size 
TranscriptomicsReliability and stability of individual differences in gene expression
Studying the causes and correlates of natural variation in gene expression in healthy populations assumes that individual differences in gene expression can be reliably and stably assessed across time. However, this is yet to be established. We examined 4-hour test-retest reliability and 10 month te...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-14844 | biostudies-arrayexpress
TranscriptomicsA data-driven approach to preprocessing Illumina 450K methylation array data
Background: As the most stable and experimentally accessible epigenetic mark, DNA methylation is of great interest to the research community. The landscape of DNA methylation across tissues, through development and in disease pathogenesis is not yet well characterised. Thus there is a need for rapid...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-43414 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hippocapus from eight different inbred mouse strains to identify substantial strain-specific variation in hippocampal gene expression
Mouse inbred strains differ in many aspects of their phenotypes, and it is known that gene expression does so too. This gives us an opportunity to isolate the genetic aspect of variation in expression and compare it to other phenotypic variables. We have investigated these issues using an eight-stra...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5429 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cholecystokinin b receptor (Cckbr)-deficient mice after chronic constriction injury
The cholecystokinin B (2) receptor knockout (Cckbr KO) protects against allodynia induced by chronic constriction injury (CCI). The mechanism of this phenomenon is unknown, but must involve persistent changes in pain modulation and/or inflammatory pathways. We performed a gene expression study in tw...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9594 | biostudies-arrayexpress
TranscriptomicsGenetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource
The Hippocampus Consortium data set provides estimates of mRNA expression in the adult hippocampus of 99 genetically diverse strains of mice including 67 BXD recombinant inbred strains, 13 CXB recombinant inbred strains, a diverse set of common inbred strains, and two reciprocal F1 hybrids. The hipp...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-84767 | biostudies-arrayexpress
GenomicsCU DPMCN Functional Genomics DAC
Data Access Committee EGAC00001001015
EGAC00001001015 | EGA
TranscriptomicsNovel antioxidative peptides with potential to reduce psoriatic changes in PBMCs
Oxidative damage contributes significantly to the pathogenesis of psoriasis. We recently developed antioxidative peptides (UPF peptides) activating the endogenous glutathione system (GSH). In the present study, we analyzed gene expression profiles in the samples of psoriasis patients to find if thes...
ORGANISM(S): Homo sapiens 
2012-08-22 | E-GEOD-40263 | biostudies-arrayexpress
TranscriptomicsSilencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage.
The gene WFS1 encodes a protein with unknown function although its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study, we aimed to find the functional networks influenced by the time-dependent silencing of WFS1 in HEK cells. We performed whole ...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-40585 | biostudies-arrayexpress
TranscriptomicsPeripheral blood RNA gene expression profiling in patients with bacterial meningitis
The aim of present study was to describe the genetic pathways activated during the community acquired bacterial meningitis (BM) by using genome-wide RNA expression profiling combined with functional annotation of transcriptional changes. We included 21 patients with BM hospitalized in 2008. The cont...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-40586 | biostudies-arrayexpress
TranscriptomicsMethylomic trajectories across human
Dynamic changes to the epigenome mediate key neurobiological and cognitive processes in the central nervous system, and also play a role in transcriptional regulation during brain development. Although the importance of DNA methylation in brain development is highlighted by the neurodevelopmental de...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-58885 | biostudies-arrayexpress
Sort   by:  
 Page size