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UnknownSelective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer.
Five to ten percent of ER+ metastatic breast cancer (MBC) tumors harbor somatic PTEN mutations. Loss of function of this tumor-suppressor gene defines a highly aggressive, treatment-refractory disease for which new therapies are urgently needed. This Phase I multipart expansion study assessed oral c...
S-EPMC8052445 | biostudies-literature
UnknownMulticenter closed-loop/hybrid meal bolus insulin delivery with type 1 diabetes.

Background

This study evaluated meal bolus insulin delivery strategies and associated postprandial glucose control while using an artificial pancreas (AP) system.

Subjects and methods

This study was a multicenter trial in 53 patients, 12-65 years of age, with type 1 diabetes for at le...
S-EPMC4183919 | biostudies-literature
UnknownMulticenter closed-loop insulin delivery study points to challenges for keeping blood glucose in a safe range by a control algorithm in adults and adolescents with type 1 diabetes from various sites.

Background

The Control to Range Study was a multinational artificial pancreas study designed to assess the time spent in the hypo- and hyperglycemic ranges in adults and adolescents with type 1 diabetes while under closed-loop control. The controller attempted to keep the glucose ranges betw...
S-EPMC4183913 | biostudies-literature
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