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UnknownDaily liver rhythms: Coupling morphological and molecular oscillations.
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S-EPMC12435289 | biostudies-literature
TranscriptomicsTranscription profiling of liver from wild type, Rev knock out and Rev-erb-alpha transcgenic mice to identify target genes of PAR bZip
Found PAR bZip target genes. The loss of circadian PAR bZip transcription factors results in epilepsy, DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine z...
ORGANISM(S): Mus musculus 
2010-06-22 | E-TABM-726 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver after miR-122 inactivation at two Zeitgeber time points, ZT0 and ZT12
Detection of transcriptome changes associated with miR-122 inactivation in mouse liver at two Zeitgeber time points, ZT0 and ZT12.
ORGANISM(S): Mus musculus 
2009-06-03 | E-TABM-692 | biostudies-arrayexpress
TranscriptomicsCIRP, a cold-inducible RNA-binding protein, modulates circadian gene expression posttranscriptionally
In mammalian tissues circadian gene expression can be driven by local oscillators or systemic signals controlled by the master pacemaker in the suprachiasmatic nucleus. Here we show that simulated body temperature cycles, but not peripheral oscillators, can control the rhythmic expression of Cold-In...
ORGANISM(S): Mus musculus 
2012-08-24 | E-GEOD-37685 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver cells during the circadian cycle at 4 hour time resolution
Cyclic regulatory systems are ubiquitous in cells and tissues. In the liver rhythms in mRNA expression are determined by the homeostatic regulation that operates on daily circumstances. In particular the specific response to nutrients, as well as systemic and peripheral circadian oscillators, contri...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35789 | biostudies-arrayexpress
GenomicsGenome-wide profiles of RNA polymerase II (Pol 2) DNA occupancy and the histone modifications H3K4me3 and H3K36me3 around the circadian cycle
To understand the transcriptional basis of circadian rhythms in mouse liver, we generated genome-wide profiles of RNA polymerase II (Pol 2) DNA occupancy and the histone modifications H3K4me3 and H3K36me3 around the circadian cycle. We found that Pol 2 occupancy at promoters and in gene bodies cycle...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35788 | biostudies-arrayexpress
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