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TranscriptomicsGlobal, comparative analysis of tissue-specific promoter CpG methylation.
Understanding cell-type-specific epigenetic codes on a global level is a major challenge after the sequencing of the human genome has been completed. Here we applied methyl-CpG immunoprecipitation (MCIp) to obtain comparative methylation profiles of coding and noncoding genes in three human tissues,...
ORGANISM(S): Homo sapiens 
2007-08-07 | E-GEOD-5548 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of differentially expressed regions between C57BL/6 and BALB/c in bone marrow derived macrophages
DNA-methylation is a vital epigenetic mark that participates in establishing and maintaining chromatin structures and in regulating gene transcription during mammalian development and cellular differentiation. Inter-individual differences in methylation patterns may represent a major source of pheno...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-14463 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukemia cell lines KG-1, U937 and THP-1 vs. normal human blood monocytes
Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor-suppressor genes. Genome wide methylation profiling of myeloid leukemia cell lines identified a large number of genes with aberrantly methylated CpG islands. Comparative ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3280 | biostudies-arrayexpress
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