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UnknownComparison of amyloid chronicity and EYO in autosomal dominant Alzheimer's disease.

Introduction

Preclinical Alzheimer's disease (AD) can be described relative to biomarker positivity onset time.

Methods

We estimated time from amyloid positivity (A+) using sampled iterative local approximation (SILA) in a longitudinal autosomal dominant AD (ADAD) sample (N = 379) wit...
S-EPMC12552894 | biostudies-literature
UnknownEmergency department outcome of elderly patients assisted by professional home services, the EPIGER study.

Background

For the elderly population living at home, the implementation of professional services tends to mitigate the effect of loss of autonomy and increases their quality of life. While helping in avoiding social isolation, home services could also be associated to different healthcare p...
S-EPMC7507819 | biostudies-literature
UnknownThe Effect of Incidental Consolidation on Management and Outcomes in COPD Exacerbations: Data from the European COPD Audit.

Objective

There is controversy regarding the significance of radiological consolidation in the context of COPD exacerbation (eCOPD). While some studies into eCOPD exclude these cases, consolidation is a common feature of eCOPD admissions in real practice. This study aims to address the quest...
S-EPMC4516303 | biostudies-literature
UnknownGlobal data set of long-term summertime vertical temperature profiles in 153 lakes.
Climate change and other anthropogenic stressors have led to long-term changes in the thermal structure, including surface temperatures, deepwater temperatures, and vertical thermal gradients, in many lakes around the world. Though many studies highlight warming of surface water temperatures in lake...
S-EPMC8339007 | biostudies-literature
UnknownExploring the link between MORF4L1 and risk of breast cancer.

Introduction

Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physica...
S-EPMC3219203 | biostudies-literature
UnknownWorldwide comparison of survival from childhood leukaemia for 1995-2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries.

Background

Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequaliti...
S-EPMC5418564 | biostudies-literature
UnknownNew-onset atrial fibrillation and chronic coronary syndrome in the CLARIFY registry.

Background and aims

Data on new-onset atrial fibrillation (NOAF) in patients with chronic coronary syndromes (CCS) are scarce. This study aims to describe the incidence, predictors, and impact on cardiovascular (CV) outcomes of NOAF in CCS patients.

Methods

Data from the international...
S-EPMC10834159 | biostudies-literature
UnknownEffect of intensive structured care on individual blood pressure targets in primary care: multicentre randomised controlled trial.

Objective

To determine the effectiveness of intensive structured care to optimise blood pressure control based on individual absolute risk targets in primary care.

Design

Pragmatic multicentre randomised controlled trial.

Setting

General practices throughout Australia, except N...
S-EPMC3502035 | biostudies-literature
UnknownThiazolidinedione use and retinal fluid in the comparison of age-related macular degeneration treatments trials.

Background

Thiazolidinediones, commonly used antidiabetic medications, have been associated with an increased risk of development of diabetic macular oedema and increased vascular endothelial cell permeability. Macular neovascularisation in age-related macular degeneration (AMD) and associat...
S-EPMC10245276 | biostudies-literature
UnknownPredominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials.

Purpose

To describe predominantly persistent intraretinal fluid (PP-IRF) and its association with visual acuity (VA) and retinal anatomic findings at long-term follow-up in eyes treated with pro re nata (PRN) ranibizumab or bevacizumab for neovascular age-related macular degeneration.

Des...

S-EPMC10282893 | biostudies-literature
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