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ProteomicsProteomic Analysis of Human Conjunctival Cells and Tears Collected with Schirmer Strips Using TimsTOF Pro
This study aimed to investigate the human tear proteins extracted from whole (W) Schirmer strips (ScS) and their two parts, the bulb (B) and the rest of the strip (R) with a comprehensive proteomic approach using a trapped ion mobility mass spectrometer, the timsTOF Pro. Eight ScS were collected fro...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD030334 | Pride
Proteomics Conjunctival cells Schirmer strips Tears Timstof pro 
ProteomicsMass spectrometric detection of keratins in tear fluid
Keratin contamination is a common problem in mass spectrometry proteomic analyses, particularly in bottom-up mass spectrometry. The purpose of this study was to determine the protein contaminants introduced during the proteomic analysis of tear fluid.Human tear fluid samples were collected using Sch...
ORGANISM(S): Homo sapiens (Human) 
2025-03-03 | PXD061409 | Pride
Tear fluid Keratins Schirmer strip Mass spectrometry Proteomics Biomarkers 
UnknownTear Sampling and Biomarker Discovery: A Robust Workflow for Routine Clinical Applications Using UHPLC-MS/MS and Schirmer Strips.
Not available
S-EPMC11900304 | biostudies-literature
UnknownProteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations.
Not available
S-EPMC8778087 | biostudies-literature
ProteomicsInvestigation of inter- and intra-day variability of tear fluid regarding flow rate, protein concentration as well as protein composition
Purpose: Determination of inter- and intra-day variations in tear flow rate, tear fluid protein concentration as well as protein composition regarding their impact for future biomarker studies.Methods: Tear fluid was collected non-invasively from 18 healthy subjects performing Schirmer tests at four...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037811 | Pride
Mass spectrometry Tear fluid Schirmer test Tear flow rate  tear volume Protein concentration 
UnknownConjunctival Swabs Reveal Higher Detection Rate Compared to Schirmer Strips for SARS-CoV-2 RNA Detection in Tears of Hospitalized COVID-19 Patients.
Not available
S-EPMC9737489 | biostudies-literature
ProteomicsSystematic Investigation of Targeted Analysis of Metabolites and Proteins in Tear Fluid
Since the sampling of tear fluid seems rather variable we sought to evaluate a protocol for combined metabolomic and proteomic analyses with regard to clinical applicability. Tear fluid was taken from twelve human volunteers at different time points using specially designed Schirmer strips. Followin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008536 | Pride
Tear fluid 
ProteomicsProteomic analysis of the thryoid eye disease tear film
Thyroid eye disease (TED) is a complex autoimmune disease that is often disfiguring and sight threatening. Recent advances have shifted the treatment paradigm from traditional immunosuppressive therapies such as corticosteroids to targeted biologic agents, such as teprotumumab (TMB; anti-IGF-1R) whi...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD066511 | Pride
Thyroid eye disease Teprotumumab Tears Ted 
GenomicsA Comprehensive Profile of microRNAs in Human Tear Fluid
We performed miRNA sequencing on RNA extracted from 32 human tear fluid samples collected using Schirmer strips from healthy individuals. Our goal was to generate a comprehensive profile of miRNA content in human tears and to examine potential demographic-specific differences among healthy samples.
ORGANISM(S): Homo sapiens 
2026-02-22 | GSE291021 | GEO
ProteomicsTear proteomics of young patients wearing glasses, orthokeratology lenses, and soft contact lenses
Contact lens-related ocular surface complications occur more often in teenagers and young adults. The purpose of this study was to determine changes in tear proteome of young patients wearing glasses (GL), orthokeratology lenses (OK), and soft contact lenses (SCL). Twenty-two young patients (10-26 y...
ORGANISM(S): Homo sapiens (Human) 
2022-11-07 | PXD029188 | Pride
Human Soft contact lens Schirmer strip Orthokeratology Tears 
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