Sort   by:  
 Page size 
UnknownBlinatumomab in pediatric relapsed/refractory B-cell acute lymphoblastic leukemia: RIALTO expanded access study final analysis.
The safety and efficacy of blinatumomab, a CD3/CD19-directed bispecific molecule, were examined in an open-label, single-arm, expanded access study (RIALTO). Children (>28 days and <18 years) with CD19+ relapsed/refractory B-cell precursor acute lymphoblastic leukemia (R/R B-ALL) received up to 5 cy...
S-EPMC8945309 | biostudies-literature
UnknownNormal ranges and genetic variants of antithrombin, protein C and protein S in the general Chinese population. Results of the Chinese Hemostasis Investigation on Natural Anticoagulants Study I Group.

Background

Inherited deficiency of antithrombin, protein C and protein S, three important, naturally occurring coagulation inhibitors, might play a major role in the occurrence of venous thromboembolism in Chinese. The establishment of age- and gender-related normal ranges of these inhibitor...
S-EPMC3128223 | biostudies-literature
UnknownRodents as sentinels for the prevalence of tick-borne encephalitis virus.

Introduction

Tick-borne encephalitis virus (TBEV) causes one of the most important flavivirus infections of the central nervous system, affecting humans in Europe and Asia. It is mainly transmitted by the bite of an infected tick and circulates among them and their vertebrate hosts. Until no...
S-EPMC3115460 | biostudies-literature
UnknownBlinatumomab in pediatric patients with relapsed/refractory acute lymphoblastic leukemia: results of the RIALTO trial, an expanded access study.
Not available
S-EPMC7381625 | biostudies-literature
UnknownNurse practitioner/physician collaborative models of care: a scoping review protocol.

Background

Before the COVID-19 pandemic, many long-term care (LTC) homes experienced difficulties in providing residents with access to primary care, typically delivered by community-based family physicians or nurse practitioners (NPs). During the pandemic, legislative changes in Ontario, Ca...
S-EPMC9934505 | biostudies-literature
GenomicsPCGP Histone-Capture bams - samples
DATA FILES FOR Histone Capture bams
EGAD00001000657 | EGA
GenomicsThe landscape of somatic mutations in epigenetic regulators across 1000 pediatric cancer genomes
To define the frequency and pattern of somatic mutations in epigenetic regulators in pediatric cancer, we sequenced 633 genes, encoding the majority of proteins involved in patterning the epigenome, in 1000 pediatric tumors spanning 21 different cancer subtypes. This analysis establishes an epigenet...
EGAS00001000449 | EGA
UnknownGlobal chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.
Epigenetic dysregulation is an emerging hallmark of cancers. We developed a high-information-content mass spectrometry approach to profile global histone modifications in human cancers. When applied to 115 lines from the Cancer Cell Line Encyclopedia, this approach identified distinct molecular chro...
S-EPMC4262138 | biostudies-literature
UnknownLethal Borna disease virus 1 infections of humans and animals - in-depth molecular epidemiology and phylogeography.
Borna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon). The known BoDV-1-endemic area is remarkably...
S-EPMC11387626 | biostudies-literature
UnknownIdentification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
Acute lymphoblastic leukemia (ALL) is a malignant disease of the white blood cells. The etiology of ALL is believed to be multifactorial and likely to involve an interplay of environmental and genetic variables. We performed a genome-wide association study of 355 750 single-nucleotide polymorphisms ...
S-EPMC3356560 | biostudies-literature
Sort   by:  
 Page size