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UnknownAge-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites.
The mechanisms by which parkin protects the adult human brain from Parkinson disease remain incompletely understood. We hypothesized that parkin cysteines participate in redox reactions and that these are reflected in its posttranslational modifications. We found that in post mortem human brain, inc...
S-EPMC8043881 | biostudies-literature
UnknownPrediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts.

Background

Cognitive decline is a debilitating manifestation of disease progression in Parkinson's disease. We aimed to develop a clinical-genetic score to predict global cognitive impairment in patients with the disease.

Methods

In this longitudinal analysis, we built a prediction al...
S-EPMC5761650 | biostudies-literature
UnknownTemporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts.

Background

Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between ventilatory settings and outcome in these p...
S-EPMC7906083 | biostudies-literature
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