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TranscriptomicsHigh-Resolution Profiling of Drosophila Replication Start Sites Reveals a DNA Shape and Chromatin Signature of Metazoan Origins
At every cell cycle, faithful inheritance of metazoan genomes requires the concerted activation of thousands of DNA replication origins. However, which genetic and chromatin features define metazoan replication start sites remains largely unknown. Here, we delineate the origin repertoire of the Dros...
ORGANISM(S): Drosophila melanogaster 
2015-04-23 | E-GEOD-65692 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling by microarray of Caenorhabditis elegans MT2124 x CB4856 RILs used for eQTL mapping
We crossed the MT2124 strain carrying the let-60 (n1046) gain of function mutation with the wild-type strain CB4856. From this cross a panel of mutation introgression recombinant inbred lines (miRILs) was generated. Using this population, the influence of genetic variation on the the let-60 (gf) mut...
ORGANISM(S): Caenorhabditis elegans 
2017-07-21 | E-MTAB-5856 | biostudies-arrayexpress
UnknownThe Path towards Endangered Species: Prehistoric Fisheries in Southeastern Brazil.
Not available
S-EPMC4939631 | biostudies-literature
ProteomicsThe concept of "RNA dependence" - Proteome-wide and quantitative identification of protein interactions dependent on RNA
The general role of RNA in the cell beyond protein biosynthesis is only beginning to emerge with little knowledge about the structural or organizational functions of RNA. In turn, functional non-coding RNAs (ncRNAs) are often identified by their regulation or impact on cellular phenotypes. However, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-06-13 | MSV000082468 | MassIVE
GenomicsExtensive remodeling of DC function by rapid maturation-induced epigenetic gene silencing
Dendritic-cell (DC) maturation involves substantial remodeling of their gene-expression program. Most research has focused on inducible gene-expression networks promoting the acquisition of new functions, such as cytokine production and enhanced T-cell-stimulatory capacity. In contrast, mechanisms t...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-58864 | biostudies-arrayexpress
UnknownFunctional and genetic markers of niche partitioning among enigmatic members of the human oral microbiome.
Not available
S-EPMC7739484 | biostudies-literature
UnknownSex-specific efficacy and safety outcomes in patients with resectable stage III non-small-cell lung cancer (NSCLC) undergoing neoadjuvant therapies: a pooled analysis of the SAKK trials 16/96, 16/00, 16/01, 16/08 and 16/14.
Not available
S-EPMC12651527 | biostudies-literature
UnknownLong-term benefit of lurbinectedin as palliative chemotherapy in progressive malignant pleural mesothelioma (MPM): final efficacy and translational data of the SAKK 17/16 study.
Not available
S-EPMC9271468 | biostudies-literature
UnknownModulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport.
Not available
S-EPMC2975716 | biostudies-literature
UnknownReal-World Outcomes of Patients With Malignant Pleural Mesothelioma Receiving a Combination of Ipilimumab and Nivolumab as First- or Later-Line Treatment.
Not available
S-EPMC11609637 | biostudies-literature
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