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TranscriptomicsRNA-Seq of murine total lung RNA samples after AAV6.2-mediated Il13 overexpression
0.9x10^11 vg of AAV6.2 vectors containing the murine Il13 cDNA were administered intratracheally to Balb/c mice (9-12 wk). As a control, AAV6.2 vectors containing non-coding “stuffer DNA” were used. To assess vector-mediated effects following AAV6.2 administration, expression in AAV-stuffer treated ...
ORGANISM(S): Mus musculus 
2015-05-31 | E-MTAB-2598 | biostudies-arrayexpress
UnknownCombined Vaccination with B Cell Peptides Targeting Her-2/neu and Immune Checkpoints as Emerging Treatment Option in Cancer.
Not available
S-EPMC9688220 | biostudies-literature
ProteomicsProteomic characterization of cerebrospinal fluid in patients with brain malignancies
Recent technological advances in molecular diagnostics through liquid biopsies hold the promise to monitor tumor evolution and treatment response of brain malignancies without the need of invasive surgical tissue accrual. Here, we implemented a new mass spectrometry-based protein analysis pipeline a...
ORGANISM(S): Homo sapiens (Human) 
2021-03-25 | PXD021984 | Pride
Brain tumor Glioblastoma Proteome Biomarker 
ProteomicsCerebrospinal fluid proteomic profiling in nusinersen-treated patients with spinal muscular atrophy Cerebrospinal fluid proteomic profiling in nusinersen-treated patients with spinal muscular atrophy
Promising results from recent clinical trials on the approved antisense oligonucleotide nusinersen in pediatric patients with 5q-linked spinal muscular atrophy (SMA) still have to be confirmed in adult patients but are hindered by a lack of sensitive biomarkers that indicate an early therapeutic res...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD016757 | Pride
Mass spectrometry (ms) Proteomics Antisense oligonucleotide (aso) Nusinersen Spinal muscular atrophy (sma) Cerebrospinal fluid (csf) 
UnknownActive immunization with a Her-2/neu-targeting Multi-peptide B cell vaccine prevents lung metastases formation from Her-2/neu breast cancer in a mouse model.
Not available
S-EPMC8904231 | biostudies-literature
TranscriptomicsmiRseq Analysis of Human Macrophages Co-cultured with MCF-7 Breast Cancer Cells
Tumor-immune cell interactions shape the immune cell phenotype, with microRNAs (miRs) being crucial components of this crosstalk. How they are transferred, and how they affect their target landscape, especially in tumor-associated macrophages (TAMs), is largely unknown. Here we aimed to define miRo...
ORGANISM(S): Homo sapiens 
2019-02-08 | E-MTAB-6885 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human bronchoalveolar lavage and lung biopsy samples in the segmental endotoxin challenge model
Segmental instillation of lipopolysaccharide (LPS) by bronchoscopy can be used as a model to safely induce transient airway inflammation in the human lung. The LPS challenge model enables investigation of cellular mechanisms involved in pulmonary inflammatory processes as well as pharmacodynamic ana...
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-13318 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling by microarray of Caenorhabditis elegans MT2124 x CB4856 RILs used for eQTL mapping
We crossed the MT2124 strain carrying the let-60 (n1046) gain of function mutation with the wild-type strain CB4856. From this cross a panel of mutation introgression recombinant inbred lines (miRILs) was generated. Using this population, the influence of genetic variation on the the let-60 (gf) mut...
ORGANISM(S): Caenorhabditis elegans 
2017-07-21 | E-MTAB-5856 | biostudies-arrayexpress
TranscriptomicsWhole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat, at different sequencing depths (RNA-Seq)
Poly(A) enriched RNA derived from the L5 DRG 7 days following L5-SNT and from naïve L5-DRG tissue was subjected to RNA-seq analysis at different sequencing depths 6 biological replicates (3 case – SNT subjected L5-DRG tissue, 3 control – naïve L5-DRG tissue). Each biological replicate was divided B4...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-53762 | biostudies-arrayexpress
TranscriptomicsIdentification of translationally deregulated proteins during inflammation
The regulation of translation is crucial for cells to rapidly adapt to changing conditions. Although the transcriptional changes under inflammatory conditions are intensely studied, not much is known about translational changes. Therefore, this study aimed at identifying translationally deregulated ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-35022 | biostudies-arrayexpress
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