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UnknownInternal motion in protein crystal structures.
Not available
S-EPMC2868237 | biostudies-literature
TranscriptomicsEfficient DNA- and virus-free engineering of cellular transcriptomic states using dCas9 ribonucleoprotein (dRNP)-complexes
For genome editing, the use of CRISPR ribonucleoprotein (RNP) complexes is well established and often the superior choice over plasmid-based or viral strategies. RNPs containing dCas9 fusion proteins, which enable the targeted manipulation of transcriptomes and epigenomes remain significantly less a...
ORGANISM(S): Homo sapiens 
2025-03-29 | GSE288075 | GEO
UnknownCrystal structure of small protein crambin at 0.48 A resolution.
Not available
S-EPMC3080141 | biostudies-literature
TranscriptomicsHK_CIA_experiment
In previous studies, we identified the fungal macrocyclic lactone (S)-curvularin (SC) as an anti-inflammatory agent using a screening system detecting inhibitors of the Janus kinase/signal transducer and activator of transcription pathway. The objective of the present study was to investigate whethe...
ORGANISM(S): Mus musculus 
2012-09-21 | E-MEXP-3180 | biostudies-arrayexpress
TranscriptomicsFollicular lymphoma in situ and partial involvement by follicular lymphoma are clona lesions that carry the t(14;18) and lack genetic secondary alterations
Follicular lymphoma (FL) is characterized by the t(14;18)(q32;q21), frequent numerical chromosomal alterations, and recurrent somatic mutations. However, no genetic studies are available for FL in situ (FLIS), a putative precursor lesion of FL. In this study, we analyzed cases of FLIS without manife...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-48548 | biostudies-arrayexpress
UnknownAssociation of Preoperative Renin-Angiotensin System Inhibitors With Prevention of Postoperative Atrial Fibrillation and Adverse Events: A Systematic Review and Meta-analysis.
Not available
S-EPMC6547087 | biostudies-literature
TranscriptomicsTranscriptome wide analysis of classically and alternatively activated macrophages
Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived human M1- and M2-like macrophage profiling (RNA-seq) to microarray and quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods an...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-36952 | biostudies-arrayexpress
TranscriptomicsRegulatory Modules Controlling Maize Inflorescence Architecture: mRNA-seq data
In this study we used the maize (Zea mays) inflorescence to investigate gene networks that modulate determinacy, specifically the decision to allow branch growth. We characterized developmental transitions by associating spatiotemporal expression profiles with morphological changes resulting from g...
ORGANISM(S): Zea mays 
2013-11-27 | E-GEOD-51047 | biostudies-arrayexpress
GenomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [human ChIP-Seq]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-31216 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide analysis of untreated, classically and alternatively activated macrophages
Analysis of human M0-, M1-, and M2-like macrophages. Total RNA was isolated from untreated, classically and aternative activated human macrophages
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-35449 | biostudies-arrayexpress
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