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ProteomicsB-cell-specific MYD88 L252P expression causes a premalignant gammopathy resembling IgM MGUS
A highly recurrent, somatic L265P mutation in the TIR domain of the signaling adapter MYD88 constitutively activates NF-kB. It occurs in nearly all human patients with Waldenström’s macroglobulinemia (WM), a B cell malignancy caused by IgM-expressing cells. Here we introduced an inducible leucine to...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-06 | PXD017292 | Pride
Lymphoid neoplasia 
UnknownHIV-1 drug resistance in the iPrEx preexposure prophylaxis trial.
Not available
S-EPMC4176446 | biostudies-literature
ProteomicsBenchmarking workflows for plasma proteomics
In this project we asses 5 different sample processing workflows for mass spectrometry based plasma proteomics and compare the results with a neat plasma workflow. The workflows evaluated includes protocols for abundant protein depletion (Top14 most abundant protein depletion and protein precipitati...
ORGANISM(S): Homo sapiens (Human) 
2026-05-04 | PXD070324 | Pride
Data independent acquisition Mass spectrometry Workflow assessment Astral Extracellular vesicles Plasma proteomics Enrichment strategies Depletion strategies 
UnknownAmyloid-β aggregates activate peripheral monocytes in mild cognitive impairment.
Not available
S-EPMC10858199 | biostudies-literature
MetabolomicsDynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) gro...

2022-12-08 | MTBLS5615 | MetaboLights
Proteomics,MultiomicsmiR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signaling in human colorectal adenocarcinoma cells
Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major unsolved problem. Consequently, predictive markers and a better understanding of resistance mechanisms are urgently needed. To investigate if the recently identified predictive miR-625-3p is functionally involved in oxPt resistance...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080762 | MassIVE
UnknownATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC.
Not available
S-EPMC10690143 | biostudies-literature
UnknownPreexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Not available
S-EPMC3079639 | biostudies-literature
UnknownESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children- a systematic review and meta-analysis.
Not available
S-EPMC9705511 | biostudies-literature
UnknownSerum Biomarkers Indicate Long-term Reduction in Liver Fibrosis in Patients With Sustained Virological Response to Treatment for HCV Infection.
Not available
S-EPMC5726250 | biostudies-literature
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