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GenomicsH2A.Z (pht1) ChIP-seq data in 968, Y0036, and swc5-del strains
After finding a QTL hotspot in a fission yeast cross of strains 968xY0036 that was apparently driven by frame shift mutation in swc5 (swc5-fs), we have determined the genome-wide occupancy of the histone variant H2AZ (PhT1). Indeed swc5 has been shown to affect H2AZ occupancy. To test the impact of ...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-04 | E-MTAB-2650 | biostudies-arrayexpress
ProteomicsProteolytic processing of CD99
The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD9...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080746 | MassIVE
TranscriptomicsTranscription profiling by array of Schizosaccharomyces pombe transcriptome during both proliferation and quiescence
Data on absolute molecule numbers are rare but will empower the modeling, understanding and comparison of cellular functions and biological systems. We quantified transcriptomes and proteomes in fission yeast during both proliferation and quiescence. This rich resource provides the first comprehensi...
ORGANISM(S): Schizosaccharomyces pombe 
2013-05-28 | E-MTAB-1153 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by high throughput sequencing of Schizosaccharomyces pombe transcriptome during both proliferation and quiescence
Data on absolute molecule numbers are rare but will empower the modeling, understanding and comparison of cellular functions and biological systems. We quantified transcriptomes and proteomes in fission yeast during both proliferation and quiescence. This rich resource provides the first comprehensi...
ORGANISM(S): Schizosaccharomyces pombe 
2012-10-26 | E-MTAB-1154 | biostudies-arrayexpress
UnknownBase editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Not available
S-EPMC9232935 | biostudies-literature
TranscriptomicsRNA sequencing of 968xY0036 fission yeast recombinant library
We generated the first recombinant strain library for fission yeast and conducted an RNA-seq based QTL study of the coding, non-coding, and antisense transcriptomes. We cross the lab strain 968 with the lab strain Y0036 to generate segregant. We used RNA-seq for both expression profiling and gentoyp...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-04 | E-MTAB-2640 | biostudies-arrayexpress
TranscriptomicsS.cerevisiae INO80 is required for promoter proximal nucleosome remodeling.
During transcription, nucleosomes are evicted from regulatory and coding regions yet chromatin structure is stable. Restoration of chromatin structure involves concerted action of chromatin modifying activities. Our analysis demonstrates a genome wide function of the INO80 remodeling complex for sta...
ORGANISM(S): Saccharomyces cerevisiae 
2016-12-24 | E-MTAB-1810 | biostudies-arrayexpress
UnknownGenetic mechanisms of resistance to targeted KRAS inhibition.
Not available
S-EPMC12340830 | biostudies-literature
UnknownEfficacy and Safety of Nivolumab Alone or in Combination With Ipilimumab in Patients With Mucosal Melanoma: A Pooled Analysis.
Not available
S-EPMC5559888 | biostudies-literature
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
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