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TranscriptomicsContinuous T cell receptor signals maintain a functional regulatory T cell pool
During development, thymocytes bearing a moderately self-reactive T cell receptor (TCR) can be selected to become regulatory T (Treg) cells. Several observations suggest that also in the periphery mature Treg cells continuously receive self-reactive TCR signals. However, the importance of this inhe...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-62532 | biostudies-arrayexpress
TranscriptomicsSubunit-specific vs. non-selective proteasome modulation in limiting inflammation in experimental colitis
Inflammatory bowel disease (IBD), comprising CrohnM-BM-4s disease and Ulcerative colitis, is characterized by chronic relapsing inflammation of the gut. It has been shown that increased proteasomal activity is associated with the expression of immunoproteasomes, which enhances NF-kB activation and t...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18163 | biostudies-arrayexpress
TranscriptomicsProtein kinase A regulated genes of Aspergillus fumigatus -FEBIT transcriptome analysis
Aspergillus fumigatus is a ubiquitous mould but also an opportunistic human pathogen causing life-threatening infections in immunocompromised patients. Survival of the fungus in different habitats depends on effective mechanisms of signal perception and transduction such as the cAMP dependent protei...
ORGANISM(S): Aspergillus fumigatus 
2014-11-30 | E-MTAB-2783 | biostudies-arrayexpress
TranscriptomicsTargeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma
Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by early metastasis into lung and bone. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic trans...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-72673 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-Epigenomics-19-11-2015-09:37:32:058-207 - samples
RNA-seq of peripheral blood samples from CLL patients.
EGAD00001001675 | EGA
Genomicsena-DATASET-DKFZ-Epigenomics-19-11-2015-09:41:10:900-208 - samples
Tagmentation-based whole-genome bisulfite sequencing of isolated cell types from healthy controls.
EGAD00001001676 | EGA
Genomics450K_DKFZ_CLL_NB
CLL and normal B cell samples using 450K
EGAD00010000871 | EGA
GenomicsAnalysis of DNA methylation in normal B cells and chronic lymphocytic leukemia
Charting differences between tumors and normal tissue is a mainstay of cancer research. However, clonal tumor expansion from complex normal tissue architectures potentially obscures cancer-specific events, including divergent epigenetic patterns. Using whole-genome bisulfite sequencing of normal B c...
EGAS00001000534 | EGA
GenomicsData Access Committee of DKFZ-Epigenomics
Data Access Committee EGAC00001000279
EGAC00001000279 | EGA
TranscriptomicsAntithetical NFATc1-Sox2 and p53-miR-200 signalling networks governs pancreatic cancer cell plasticity and tumour progression
Pancreatic ductal adenocarcinoma (PDAC) cells undergo epithelial mesenchymal transdifferentiation (EMT) in adaption to environmental cues, including inflammation, a process that combines tumour cell dedifferentiation with dissemination and acquisition of stemness features. However, the mechanisms co...
ORGANISM(S): Mus musculus 
2015-02-10 | E-MTAB-2324 | biostudies-arrayexpress
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