Subunit-specific vs. non-selective proteasome modulation in limiting inflammation in experimental colitis

ABSTRACT: Inflammatory bowel disease (IBD), comprising CrohnM-BM-4s disease and Ulcerative colitis, is characterized by chronic relapsing inflammation of the gut. It has been shown that increased proteasomal activity is associated with the expression of immunoproteasomes, which enhances NF-kB activation and thus promotes inflammation in IBD-patients. Here, we investigate whether modulation of the proteasomal activity is a suitable therapeutic approach to limit inflammation in colitis. This concept was tested in two different experimental setups. First, development of dextran sulfate sodium (DSS)-induced colitis was tested in lmp7-/--mice, which lack the essential immunoproteasome-subunit LMP7 or in wildtype-mice treated with the proteasome inhibitor bortezomib. Compared to WT mice, lmp7-/- mice reve

ORGANISM(S): Mus musculus

SUBMITTER: Hans-Joachim Mollenkopf 

PROVIDER: E-GEOD-18163 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress