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ModelsShrestha2010_HypoCalcemia_PTHresponse
This a model from the article: A mathematical model of parathyroid hormone response to acute changes in plasma ionized calcium concentration in humans. Shrestha RP, Hollot CV, Chipkin SR, Schmitt CP, Chait Y. Math Biosci.2010 Jul;226(1):46-57. 20406649, ...
2024-09-02 | BIOMD0000000276 | BioModels
ModelsShrestha2010_HyperCalcemia_PTHresponse
This a model from the article: A mathematical model of parathyroid hormone response to acute changes in plasma ionized calcium concentration in humans. Shrestha RP, Hollot CV, Chipkin SR, Schmitt CP, Chait Y. Math Biosci.2010 Jul;226(1):46-57. 20406649, ...
2024-09-02 | BIOMD0000000277 | BioModels
TranscriptomicsMicroarray analysis of human pediatric omental biopsies obtained from uremic patients, patients on peritoneal dialysis or healthy controls
Cardiovascular disease (CVD) is exceedingly severe in patients with chronic kidney disease (CKD) and further aggravated by peritoneal dialysis (PD), exposing the patients to excessive amounts of intraperitoneal glucose. Children are devoid of pre-existing CVD and give insight into specific uremia an...
ORGANISM(S): Homo sapiens 
2018-04-12 | E-MTAB-5695 | biostudies-arrayexpress
TranscriptomicsGlucose degradation products induce arteriolar endothelial tight junction disintegration and apoptosis, and accelerate vasculopathy in children with chronic kidney disease
Cardiovasculopathy is the leading cause of death; patients with chronic kidney disease (CKD) are at particularly high risk. The pathophysiological role of accumulating reactive metabolites in CKD such as glucose degradation products (GDP) is uncertain. Large amounts of GDP are absorbed from conventi...
ORGANISM(S): Homo sapiens 
2025-01-10 | E-MTAB-9646 | biostudies-arrayexpress
TranscriptomicsRNA expression profiling in primary and immortalized human mesothelial cells, and in human vein and microvascular endothelial cells
Mesothelial cells, which interact with endothelial cells, are widely used in research including cancer and drug development, have not been comprehensively profiled. We therefore performed RNA sequencing of polarized, primary peritoneal (HPMC) and immortalized pleural mesothelial cells (MeT-5A), and ...
ORGANISM(S): Homo sapiens 
2023-05-24 | E-MTAB-12021 | biostudies-arrayexpress
TranscriptomicsThe Mpn1 exonuclease defines a novel spliceosomal snRNA decay pathway dependent on Rrp6 and Lsm2-8 complex
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-08-08 | E-GEOD-60198 | biostudies-arrayexpress
Transcriptomicsyeast U6 3' RACE
Mpn1 proteins are evolutionarily conserved exonucleases that modify spliceosomal U6 small nuclear RNAs (snRNAs) post-transcriptionally. Mutations in the human MPN1 gene are associated to the genodermatosis Clericuzio-type poikiloderma with neutropenia (PN). Mpn1 deficiency leads to aberrant U6 3M-bM...
ORGANISM(S): Schizosaccharomyces pombe 
2014-08-08 | E-GEOD-60195 | biostudies-arrayexpress
UnknownImmunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study.
Not available
S-EPMC11639114 | biostudies-literature
TranscriptomicsGlobal 3' RACE in yeast and humans
Mpn1 proteins are evolutionarily conserved exonucleases that modify spliceosomal U6 small nuclear RNAs (snRNAs) post-transcriptionally. Mutations in the human MPN1 gene are associated to the genodermatosis Clericuzio-type poikiloderma with neutropenia (PN). Mpn1 deficiency leads to aberrant U6 3M-bM...
ORGANISM(S): Homo sapiens 
2014-08-08 | E-GEOD-60197 | biostudies-arrayexpress
TranscriptomicsFission yeast Cactin restricts telomere transcription and elongation by promoting Rap1 pre-mRNA splicing and protein stabilization
RNA transcriptome analysis of S.pombe fission yeast cells deleted for cay1+/SPBC2F12.12c (cay1D) and wildtype The transcriptome of cay1+ deleted fission yeast cells was characterized and compared to wildtype yeasts to identify differentially expressed genes controlled by Cay1 on a transcriptional or...
ORGANISM(S): Schizosaccharomyces pombe 
2014-09-27 | E-GEOD-61792 | biostudies-arrayexpress
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