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TranscriptomicsRegulation of the Mycobacterium tuberculosishypoxic response gene encoding alpha-crystallin
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-05 | E-GEOD-8639 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis grown at reduced oxygen tension to identify regulators of the hypoxic response
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-312 | biostudies-arrayexpress
UnknownDiscovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
Not available
S-EPMC6257622 | biostudies-literature
TranscriptomicsInhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program
An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-21 | E-GEOD-8839 | biostudies-arrayexpress
UnknownGenetic Approaches to Facilitate Antibacterial Drug Development.
Not available
S-EPMC4484962 | biostudies-literature
UnknownTargeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
Not available
S-EPMC4667793 | biostudies-literature
UnknownImproved tetracycline repressors for gene silencing in mycobacteria.
Not available
S-EPMC2665214 | biostudies-literature
UnknownTargeting protein biotinylation enhances tuberculosis chemotherapy.
Not available
S-EPMC6151865 | biostudies-literature
UnknownIdentification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of <i>Mycobacterium tuberculosis</i>.
Not available
S-EPMC11915372 | biostudies-literature
UnknownSynthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation.
Not available
S-EPMC10120654 | biostudies-literature
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