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MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
UnknownRandomized phase II study of erlotinib in combination with placebo or R1507, a monoclonal antibody to insulin-like growth factor-1 receptor, for advanced-stage non-small-cell lung cancer.
Not available
S-EPMC5320944 | biostudies-literature
TranscriptomicsGene expression profile of cell lines 2106T, H1975 and MeWo after knockdown of PAEP.
Gene expression profile was analyzed after knockdown of PAEP in lung cancer cell lines 2106T and H1975 as well as in skin cancer cell line MeWo. The aim of the study was to investigate the role of PAEP and its protein product glycodelin in lung cancer cell lines. Cells were treated with a control si...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-60888 | biostudies-arrayexpress
ProteomicsRespiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice [Lung data]
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases but switching to less harmful products (modified-risk tobacco products) can be an alternative for smokers who would otherwise not quit. In an 18-month chronic carcinogenicity/toxicity study in A/J mice ...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-13 | PXD016460 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsRespiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice [RNE data]
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases but switching to less harmful products (modified-risk tobacco products) can be an alternative for smokers who would otherwise not quit. In an 18-month chronic carcinogenicity/toxicity study in A/J mice ...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-13 | PXD016466 | Pride
Lc-msms Respiratory nasal epithelium Mouse Systems toxicology Itraq 
TranscriptomicsA Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Modified Risk Tobacco Products, CHTP 1.2 and THS 2.2, Compared with Conventional Cigarettes
Smoking is one of the major modifiable risk factors in the development and progression of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Modified-risk tobacco products (MRTP) are being developed to provide substitute products for smokers who are unable or unwilling t...
ORGANISM(S): Mus musculus 
2019-04-18 | E-MTAB-7444 | biostudies-arrayexpress
TranscriptomicsCombined Chronic Toxicity and Carcinogenicity of Aerosol from a Heated Tobacco Product (mRNA data)
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases but switching to less harmful products (modified-risk tobacco products) can be an alternative for smokers who would otherwise not quit. In an 18-month chronic carcinogenicity/toxicity study in A/J mice ...
ORGANISM(S): Mus musculus 
2020-08-17 | E-MTAB-8540 | biostudies-arrayexpress
ProteomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice.
Combustible cigarette smoking has major impact on human health. In order to reduce smoking-related health risk, the tobacco industry is developing modified risk tobacco products (MRTP). To assess the potential of such a prototype (pMRTP) to reduce health risk, we used C57BL/6 mice, model of chronic ...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-04 | PXD001369 | Pride
Systems toxicology  tobacco-heating  itraq  mouse 
TranscriptomicsA Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Modified Risk Tobacco Products, CHTP 1.2 and THS 2.2, Compared with Conventional Cigarettes (miRNA data)
Smoking is one of the major modifiable risk factors in the development and progression of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Modified-risk tobacco products (MRTP) are being developed to provide substitute products for smokers who are unable or unwilling t...
ORGANISM(S): Mus musculus 
2019-04-18 | E-MTAB-7892 | biostudies-arrayexpress
TranscriptomicsThirteen-week Nose-only Inhalation Exposures of Propylene Glycol Aerosols in Sprague Dawley Rats with a Lung Systems Toxicology Analysis.
Propylene glycol (PG) is a common carrier in e-vapor formulations and its properties have been extensively studied. In this 13-week subchronic nose-only inhalation study, Sprague Dawley rats were exposed to filtered air (sham control group), propylene glycol/water (PG/W; 90:10) or a propylene glycol...
ORGANISM(S): Rattus norvegicus 
2021-09-07 | E-MTAB-10006 | biostudies-arrayexpress
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