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TranscriptomicsTranscription profiling of Drosophila SL2 cells treated with E. coli with RNAi knock-down of Dsor1 or Gap1
Experiment was undertaken to compare the transcriptional response of SL2 cells to E. coli treatment with the response to modulated ERK/MAPK activity through RNAi of Dsor1 or Gap1.
ORGANISM(S): Drosophila melanogaster 
2009-10-01 | E-MEXP-2145 | biostudies-arrayexpress
TranscriptomicsRadicicol treatment of Drosophila cells
Drosophila S2 cells were treated with Heat-shock protein 90 (Hsp90) inhibitor radicicol for 15min, 30min and 1h. Poly(A) RNA was isolated and sequenced. Kinetics of transcriptional response to Hsp90 inhibition
ORGANISM(S): Drosophila melanogaster 
2012-05-14 | E-GEOD-35812 | biostudies-arrayexpress
GenomicsHeat-shock protein 90 globally targets paused promoters and regulates environment-induced gene expression
In this study we provide evidence that Hsp90 binds chromatin at specific sites close to several TSS in Drosophila S2 cell line. In addition of finding a preference for stalled promoter regions of annotated genes, we uncover many intergenic Hsp90 binding sites coinciding with non-annotated transcript...
ORGANISM(S): Drosophila melanogaster 
2012-05-14 | E-GEOD-31226 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of EJC depletion by RNA-Seq using the SOLiD platform (Applied Biosystems)
Signaling pathways are controlled by a vast array of post-translational mechanisms. By contrast, little is known regarding the mechanisms that regulate the expression of their core components. We conducted an RNAi screen in Drosophila for factors modulating RAS/MAPK signaling and identified the Exon...
ORGANISM(S): Drosophila melanogaster 
2010-10-19 | E-GEOD-24012 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Infrared-A radiation induced transcriptom of human skin fibroblasts.
Background: Infrared A radiation (IRA 760-1440 nm) is a major component of solar radiation and, similar to ultraviolet (UV) radiation, causes photoaging of human skin by increasing the expression of matrixmetalloproteinase-1 (MMP-1) expression in human skin fibroblasts. This gene-regulatory effect ...
ORGANISM(S): Homo sapiens 
2010-07-10 | E-GEOD-17046 | biostudies-arrayexpress
UnknownEarly-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations.
Not available
S-EPMC6005705 | biostudies-literature
TranscriptomicsExpression profiles of the hippocampus of Rsk2-KO mice
Coffin–Lowry Syndrome (CLS) is a syndromic form of mental retardation caused by loss of function mutations in the X-linked RPS6KA3 gene, which encodes Rsk2, a serine/threonine kinase involved in spatial memory. We analyzed hippocampal gene expression profiles in Rsk2-KO mice to identify changes in ...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-22137 | biostudies-arrayexpress
TranscriptomicsEffect of mago nashi depletion on gene expression in Drosophila S2R+ cells
This study was designed to identify changes in gene expression resulting from depletion of Mago nashi (Mago), a core subunit of the exon junction complex. Drosophila S2R+ cells were treated with double-stranded RNA targeting either LacZ or Mago for 6 days. Poly(A)+ RNA was purified from each sample ...
ORGANISM(S): Drosophila melanogaster 
2010-10-20 | E-GEOD-23997 | biostudies-arrayexpress
UnknownThe global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12687902 | biostudies-literature
UnknownInborn errors of type I IFN immunity in patients with life-threatening COVID-19.
Not available
S-EPMC7857407 | biostudies-literature
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