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TranscriptomicsCharacterization of human embryonic stem cells with features of neoplastic progression
Cultured human embryonic stem (hES) cells can acquire genetic and epigenetic changes that make them vulnerable to transformation. As hES cells with cancer-cell characteristics share properties with normal hES cells, such as self-renewal, teratoma formation and the expression of pluripotency markers,...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13995 | biostudies-arrayexpress
TranscriptomicsDirect conversion of human fibroblasts to multilineage blood progenitors
Similar to embryo-derived stem cells, application of human induced pluripotent stem cells (iPSCs) is limited by our understanding of lineage specification. Here, we demonstrate the ability to generate progenitors and mature cells of the hematopoietic fate directly from human dermal fibroblasts witho...
ORGANISM(S): Homo sapiens 
2010-10-20 | E-GEOD-24621 | biostudies-arrayexpress
TranscriptomicsNotch-HES1 signaling axis controls hemato-endothelial fate decisions of human embyronic and induced pluripotent cells
Notch signaling regulates several cellular processes including cell fate decisions and proliferation in both invertebrates and mice. However, comparatively less is known about the role of Notch during early human development. Here, we examined the function of Notch signaling during hematopoietic lin...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-47466 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human children with mental retardation and immediate family members
The cause of mental retardation in one-third to one-half of all affected individuals is unknown. Microscopically-detectable chromosomal abnormalities are the most frequent recognized cause, but gain or loss of chromosomal segments that are too small to be seen by conventional cytogenetic analysis ha...
ORGANISM(S): Homo sapiens 
2008-06-21 | E-GEOD-7226 | biostudies-arrayexpress
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