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MetabolomicsLeveraging the Metabolic Fingerprint of Sleep Deprivation and Sleep Restriction for Forensic Applications: A Machine Learning Study in Oral Fluid Metabolomics

As sleep loss leads to accidents and impaired safety, a direct metabolic marker would be beneficial for forensic interpretation.

In a sufficiently powered, randomized, controlled, crossover trial under realistic conditions, we examined the salivary metabolome of 20 young men (habitual slee...

2026-05-21 | MTBLS11413 | MetaboLights
MetabolomicsJasmonate-mediated stomatal closure under elevated CO2 revealed by time-resolved metabolomics
Foliar stomatal movements are critical for regulating plant water loss and gas exchange. Elevated carbon dioxide (CO2) levels are known to induce stomatal closure. However, the current knowledge on CO2 signal transduction in stomatal guard cells is limited. Here we report metabolomic responses of Br...
2017-04-25 | MTBLS312 | MetaboLights
TranscriptomicsLeishmania major modulates autophagy in host macrophages during intracellular differentiation
Autophagy generally participates in innate immunity by elimination of intracellular pathogens. However, many of them developed successful strategies to counteract their autolysosomal digestion and lastly to exploit this catabolic cellular process. Protozoan parasites of the genus Leishmania are the ...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-52624 | biostudies-arrayexpress
TranscriptomicsLeishmania major infection-induced changes in the small RNA transcriptome of host macrophages.
Protozoan parasites of the genus Leishmania are the causative agent of leishmaniasis, one of the 13 most important tropical diseases. Leishmania persists as endo-parasite in host macrophages, where it uses multiple strategies to manipulate the microbicidal host cell functions and to escape from the ...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-58369 | biostudies-arrayexpress
TranscriptomicsPrenatal stress-induced programming of genome-wide promoter DNA methylation in 5-Htt deficient mice
The serotonin transporter (5-HTT) gene-linked polymorphic region has been suggested to play a modulatory role in mediating the effects of early-life stress on psychopathology rendering carriers of the low-expression short (s)-allele more vulnerable to environmental adversity in later life. Here we a...
ORGANISM(S): Mus musculus 
2014-11-18 | E-GEOD-51634 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the cytosine methylation profile in Arabidopsis thaliana crown galls
Integration of the bacterial T-DNA into the plant genome by virulent agrobacteria causes crown gall development on many plant species. Plant tumor development shares fundamental similarities with mammalian cancer progression despite obvious differences in initiation of tumor development. For neoplas...
ORGANISM(S): Arabidopsis thaliana 
2013-02-18 | E-GEOD-37680 | biostudies-arrayexpress
UnknownDiastereoselective formation of homochiral flexible perylene bisimide cyclophanes and their hybrids with fullerenes.
Not available
S-EPMC8653996 | biostudies-literature
TranscriptomicsIdentification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke
Because most human stroke victims are elderly, studies of experimental stroke in the aged rather than the young rat model may be optimal for identifying clinically relevant cellular responses, as well for pinpointing beneficial interventions. We employed the Affymetrix platform to analyze the whole-...
ORGANISM(S): Rattus norvegicus 
2014-04-22 | E-GEOD-55260 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of human CD34+ stem cells differentiating into macrophage-like cells
Transcriptional profiling of CD34 stem cell differentiation into macrophage-like cells
ORGANISM(S): Homo sapiens 
2008-10-15 | E-MEXP-1826 | biostudies-arrayexpress
TranscriptomicsGene expression in soleus muscle of mouse inbred strains LG/J and SM/J
Variability in muscle mass significantly impacts energy expenditure, influencing preponderance to obesity and recently it has been reported that there is a positive association between muscle mass and longevity in older adults. Muscle fibre cross-sectional area (CSA) and proportion of different fibr...
ORGANISM(S): Mus musculus 
2017-01-23 | E-MTAB-5290 | biostudies-arrayexpress
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