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TranscriptomicsTranscriptome comparison of murine wild-type and dumbo retinas at P15
Hmx1 is a transcription factor expressed in the developing eye and ear and in some other parts of the nervous system. Dumbo mice are carrying the Hmx1 p.Q64X loss-of-function mutation (Munroe et al., 2009. BMC Developmental Biology). Transcriptomic analyses of this mouse model allows to decipher bio...
ORGANISM(S): Mus musculus 
2013-07-24 | E-GEOD-47002 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Danio rerio 
2016-02-18 | E-GEOD-51018 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Danio rerio 
2016-02-18 | E-GEOD-51013 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Mus musculus 
2016-02-15 | E-GEOD-51012 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and Rpe65-/- mouce retinae to characterize gene response in Rpe65-/- mouse model of Lebers congenital amaurosis during progression of the disease.
To characterize gene response in RPE65-/- mouse model of Leber's congenital amaurosis during progression of the disease, we analyzed differential gene expression in retinae early in the development of the disease, namely before and at the onset of photoreceptor cell death in knock-out mice of 2, 4 a...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3249 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Mus musculus 
2016-02-18 | E-GEOD-51019 | biostudies-arrayexpress
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