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GenomicsLarge-scale methylation domains mark a functional subset of neuronally expressed genes
DNA methylation is essential for embryonic and neuronal differentiation, but the function of most genomic DNA methylation marks are poorly understood. Generally the human genome is highly methylated (>70%) except for CpG islands and gene promoters. However, it was recently shown that the IMR90 human...
ORGANISM(S): Homo sapiens 
2011-06-23 | E-GEOD-25930 | biostudies-arrayexpress
TranscriptomicsExamination of gene expression in human placenta using RNA-seq
As genome-scale DNA methylation sequencing technologies have improved it has become apparent that tissue-specific methylation can occur not only at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated ...
ORGANISM(S): Homo sapiens 
2013-03-28 | E-GEOD-39776 | biostudies-arrayexpress
TranscriptomicsComparison of DNA methylation in human tissues
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-03-28 | E-GEOD-39777 | biostudies-arrayexpress
GenomicsExamination of four human tissue samples by MethylC-seq
As genome-scale DNA methylation sequencing technologies have improved it has become apparent that tissue-specific methylation can occur not only at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated ...
ORGANISM(S): Homo sapiens 
2013-03-28 | E-GEOD-39775 | biostudies-arrayexpress
GenomicsRole of DNMT3B in the regulation of early neural and neural crest specifiers
The de novo DNA methyltransferase DNMT3B functions in establishing DNA methylation patterns during development. We performed RNAi knockdown of DNMT3B in human embryonic stem cells (ESCs) in order to investigate the mechanistic contribution of DNMT3B on DNA methylation and early neuronal differentiat...
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-32268 | biostudies-arrayexpress
GenomicsDNA methylation in mammalian placentas
Over the last 20-80 million years the mammalian placenta has taken on a variety of morphologies through both divergent and convergent evolution. Recently we have shown that the human placenta genome has a unique epigenetic pattern of large partially methylated domains (PMDs) and highly methylation ...
ORGANISM(S): Monodelphis domestica 
2015-08-05 | E-GEOD-63330 | biostudies-arrayexpress
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