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TranscriptomicsTranscription profiling by array of mouse islet of Langerhans with FoxA1/A2 knock outs
RNAs were extracted from 10 week adult control and FoxA1/A2 Pdx1CreERT2 mice. FoxA1 and FoxA2 are ablated in adult mouse Beta cells by tamoxifen adminstration. We aim to study the roles of FoxA1 and FoxA2 on islet gene expression when they are knocked down.
ORGANISM(S): Mus musculus 
2010-06-23 | E-MTAB-219 | biostudies-arrayexpress
GenomicsThe Nucleosome Map of the Mammalian Liver
We report the genome-wide map of nucleosome positions in the mouse liver, with emphasis on transcriptional start sites, CpG islands, Foxa2 binding sites, and their correlation with gene expression. Despite the heterogeneity of liver tissue, we could clearly discern the nucleosome pattern of the pred...
ORGANISM(S): Mus musculus 
2011-04-30 | E-GEOD-26729 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse pancreatic islets on day 14.5 of pregnancy
The inability of the beta-cell to meet the demand for insulin brought about by insulin resistance leads to type 2 diabetes. In adults, beta-cell replication is one of the mechanisms thought to cause the expansion of beta-cell mass. Efforts to treat diabetes require knowledge of the pathways that dri...
ORGANISM(S): Mus musculus 
2010-06-26 | E-MTAB-120 | biostudies-arrayexpress
TranscriptomicsDifferential expression of sorted Alpha and Beta cells
The goal of this experiment is to identify genes differentially expressed in FACS-sorted Alpha and Beta cells.
ORGANISM(S): Homo sapiens 
2011-07-23 | E-MTAB-465 | biostudies-arrayexpress
TranscriptomicsDifferential expression of representative sorted pancreatic cells
The goal of this experiment is to identify genes differentially expressed in representative pancreatic FACS-sorted cell types.
ORGANISM(S): Homo sapiens 
2011-07-26 | E-MTAB-463 | biostudies-arrayexpress
TranscriptomicsTranscriptional and epigenetic profiling of the progression of hESCs to beta cells
To characterize the epigenetic programs that underlie pancreas differentiation, we have generated genome-scale maps of H3K4me and H3K27me3 patterns by ChIP-seq and determined expression profiles by RNA-seq from undifferentiated human ESCs, four intermediate differentiated stages (definitive endoderm...
ORGANISM(S): Homo sapiens 
2013-02-08 | E-MTAB-1086 | biostudies-arrayexpress
TranscriptomicsChIP profiling by array of histone modifications in normal human islets
This experiment used ChIP-seq technology to create a genome-wide profile of histone marks in normal human pancreatic islets. In the current work we analyzed two histone marks associated with gene expression (H3K4me3, H3K4me1) and marks associated with gene repression(H3K27me3). Each mark was anayze...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-MTAB-191 | biostudies-arrayexpress
GenomicsChIP-Seq of human normal pancreatic islets with anti-histone antibodies to analyse histone modifications
This experiment used ChIP-seq technology to create a genome-wide profile of histone marks in normal human pancreatic islets. In the current work we analyzed two histone marks associated with gene expression (H3K4me3, H3K4me1) and marks associated with gene repression(H3K27me3). Each mark was anayze...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-MTAB-189 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of human pancreatic endocrine cells from Juvenile, adult control and type 2 diabetic donors.
We successfully sequenced and annotated more than 400 cells from child, adult control, type 1 diabetes and type 2 diabetes donors. We detect donor-type specific transcript variation. We also report that cells from child donors have less defined gene signature. Cells from type 2 diabetes donors resem...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-83139 | biostudies-arrayexpress
GenomicsHistone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (ChIP-Seq)
We report the genomic regions enriched in Histone Deacetylase 3 (HDAC3) in mouse bone marrow derived macrophages. Furthermore, we also report the genomic acetylation pattern on Histone 3, Lysine 9 (H3K9) in macrophages with and without HDAC3 and/or treated with Th2 cytokine IL-4. HDAC3 enriched gen...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-33596 | biostudies-arrayexpress
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