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TranscriptomicsMicroRNA expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate
Current knowledge of prostate cancer genomes is largely based on relatively small patient cohorts using single modality analysis platforms. Here we report concordant assessment of DNA copy number, mRNA and microRNA expression and focused exon resequencing in prostate tumors from 218 patients with pr...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-21036 | biostudies-arrayexpress
UnknownPrevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer.
Not available
S-EPMC3753703 | biostudies-literature
UnknownPIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer.
Not available
S-EPMC5087318 | biostudies-literature
UnknownGenetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.
Not available
S-EPMC5477828 | biostudies-literature
TranscriptomicsCopy number alteration burden predicts prostate cancer relapse: Agilent 1M aCGH data for human primary prostate cancer samples
Prostate cancer is the most common malignancy in men. Yet, the modest benefit of treatment highlights the unmet need for prognostic biomarkers in prostate cancer (1). Few large prostate oncogenome resources currently exist that combine the molecular and clinical outcome data necessary for prognost...
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-54691 | biostudies-arrayexpress
Transcriptomics18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.
Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for th...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-21217 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Precision Oncology
Prostate cancers exhibit a spectrum of molecular aberrations of which a substantial subset are amenable to targeted therapeutics. To determine the diversity of somatic alterations present in metastasis within and between individuals we characterized the genomic landscapes of 176 tumors acquired from...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-74685 | biostudies-arrayexpress
TranscriptomicsSubstantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
Intraindividual tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases in a...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-77930 | biostudies-arrayexpress
TranscriptomicsGenomic and Transcriptomic Hallmarks of Poorly-Differentiated and Anaplastic Thyroid Cancers
BACKGROUND. Poorly-differentiated (PDTC) and anaplastic (ATC) thyroid cancers are rare and frequently lethal tumors, which so far have not been subjected to comprehensive genetic characterization. METHODS. We performed next generation sequencing of 341 cancer genes in 117 PDTCs and ATCs, and a tran...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-76039 | biostudies-arrayexpress
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